Adrenogic Agonist and Adrenergic Blockers

Question 1

Autonomic Nervous System consists of

Answer 1

Sympathetic and Parasympathetic

Question 2

Flight or flight is which nervous system, parasympathetic or sympathetic?

Answer 2

Sympathetic

Question 3

Is rest and digest apart of sympathetic or parasympathetic?

Answer 3

Parasympathetic

Question 4

What neurotransmitter works with the cholinergic drugs?

Answer 4

Acetylcholine

Question 5

Acetylcholine goes to what receptor site?

Answer 5

Muscarinic

Question 6

Adrenergic antagonist and cholinergic are

Answer 6

Have the same rest and digest effect

Question 7

Adrenergic agonist and anticholinergic

Answer 7

Have the same flight or fight effect

Question 8

What system and what receptor does Acetylcholine work in?

Answer 8

Parasympathetic system and somatic (efferent) receptors

Question 9

What happens when acetylcholine goes to musiniric receptors.

Answer 9

Rest and digest, it calms the body down

Question 10

What happens when acetylcholine goes to the nicotine receptors?

Answer 10

It stimulates that nicotine receptors

Question 11

Characteristics of Muscarinic receptors

Answer 11

Located in the smooth muscles and myocardium (autonomic or involuntary muscles)

Stimulates by acetylcholine

Question 12

Characteristics of Nicotinic receptors

Answer 12

Located in the skeletal muscles ( somatic or voluntary muscles)

Stimulated by ACh

Question 13

Is autonomic system involuntary or voluntary?

Answer 13

Involuntary

Question 14

What are cholinergic side effects.?

Answer 14

Excessive muscarinic stimulation

General: Dizziness, poor perfusion to the brain due to low BP

Eye: Blurred vision due to miosis and loss of accommodation ( poor vision) in dim light

Lung: SOB due to bronchonstriction, increase in bronchial secretions

Cardiovascular: bradycardia, dysrythmias which lead to low be and dizziness

Urinary: urgency, frequency

Exocrine glands: hypersalvation

Excessive nicotinic stimulation

Muscle cramps, fasciculation (muscle twitching)

Question 15

What does acetylcholine do to the brain?

Answer 15

Stimulates the brain

Question 16

What happens when there is excessive acetylcholine in the central nervous system?

Answer 16

Excitation, seizure

Question 17

What is the reversal agent or anti cholinergic drug called?

Answer 17

Atropine

Question 18

Reasons to not give cholinergic drugs (contraindication)

Answer 18

Pregnancy / lactation

GI obstruction (abdominal pain)

GU obstruction (ureter/ urethra stone)

Question 19

Caution reasons for cholinergic drugs

Answer 19

Seizure
Asthma
PUD (peptic ulcer disease) ( when you take cholinergic hydrochloric acid secretions increase)
Bradycardia and Low BP

Question 20

What do cholinergic drugs do?

Answer 20

Stimulate the receptor sites for acetylcholine

Question 21

What do Anticholinergic drugs do?

Answer 21

Suppresses/blocks receptor sites for acetylcholine

Inhibits action of acetylcholine

Question 22

Anticholinergic side effects

Answer 22

GI: decrease secretions , hypoactive bowel sounds

Eye: mydriasis , decrease accommodation in bright light (photophobia)

Heart: increase heart rate and BP

Lungs: bronchodilation , decrease bronchosecretions ,

GU: relax muscle , increase sphincter constriction ( urinary retention)

CNS: drowsiness, decrease tremors

Used to reverse cholinergic

Question 23

Peripheral

Answer 23

Outside the brain and spinal cord

Question 24

Autonomic (visceral)

Answer 24

Involuntary, acts on smooth muscle and organs

Question 25

Somatic

Answer 25

Voluntary, innervates skeletal muscles

Question 26

Central nervous system consists of

Answer 26

The brain and spinal cord

Question 27

Adrenergic receptors Alpha 1. ( Bear )

Answer 27

Blood vessels, eye, bladder, prostate What does it do : peripheral vasoconstriction will increase BP Mydriasis (eye dilation ) Urinary retention

Question 28

Adrenergic receptors Alpha 2 (sleepy chicken )

Answer 28

What does it do: Prevents norepinephrine release Promotes vasodilation which decreases BP Miosis

Question 29

Adrenergic receptor Beta 1

Answer 29

Location: heart, blood vessels What does it do: Increased heart rate and cardiac output

Question 30

Adrenergic receptor Beta 2

Answer 30

Location: Lung What does it do: Bronchodilation

Question 31

Adrenergic receptors Dopaminergic

Answer 31

Location: kidney, mesentery, coronary Only works with dopamine What does it do: increases contractility of myocardium , diuresis and natriuresis, increased circulation to mesentery, coronary artery and cerebral artery

Question 32

Selective drugs

Answer 32

Works on specific receptors A1, A2, B1,B2 Albuterol is a selective beta 2 agonist Opens airways, helps asthma and COPD At higher dose becomes non selective and stimulating beta 1 can cause tachycardia

Question 33

Non selective drugs

Answer 33

Effects different receptors at the same time, activates alpha 1, beta 1 and 2 Increases BP and HR , opens airway Epinephrine

Question 34

Do not give Adergernic “bear drugs” to people with

Answer 34

Glaucoma BPH

Question 35

Adrenergic blockers can work in what two ways?

Answer 35

Directly by occupying receptors - Block effects of Adrenergic neurotransmitter Indirectly by inhibiting telecast of neurotransmitters (epi and norepinephrine) - Block alpha and beta receptor sites

Question 36

Adrenergic effects (bear)

Answer 36

``` Bronchodilation Mydriasis Increase heart rate Peripheral vasoconstriction Shunting from GI, GU, Skin Increase BP Decrease secretions Decrease GI motility Increase coagulability Bladder relaxes, sphincter/ prostate closes Uterus relaxes Glycogen Lysis ```

Question 37

Cholinergic effects (sleepy chicken)

Answer 37

``` Bronchoconstriction Myosis Decrease Heart rate Peripheral vasodilation Increase circulation to GI,GU,Skin Decrease BP Increase secretions Increase GI motility Normal coaguability Bladder contracts, bladder spinchter/prostate open Uterus contracts Glycerin synthesis ```

Question 38

What will acetylcholine do the peripheral nervous system

Answer 38

Acetylcholine will rest and digest ( sleepy chicken) on peripheral nervous system but will stimulate the brain