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Pharm > Adrenogic Agonist and Adrenergic Blockers > Flashcards

Adrenogic Agonist and Adrenergic Blockers Flashcards

1
Q

Autonomic Nervous System consists of

A

Sympathetic and Parasympathetic

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2
Q

Flight or flight is which nervous system, parasympathetic or sympathetic?

A

Sympathetic

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3
Q

Is rest and digest apart of sympathetic or parasympathetic?

A

Parasympathetic

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4
Q

What neurotransmitter works with the cholinergic drugs?

A

Acetylcholine

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5
Q

Acetylcholine goes to what receptor site?

A

Muscarinic

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6
Q

Adrenergic antagonist and cholinergic are

A

Have the same rest and digest effect

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7
Q

Adrenergic agonist and anticholinergic

A

Have the same flight or fight effect

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8
Q

What system and what receptor does Acetylcholine work in?

A

Parasympathetic system and somatic (efferent) receptors

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9
Q

What happens when acetylcholine goes to musiniric receptors.

A

Rest and digest, it calms the body down

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10
Q

What happens when acetylcholine goes to the nicotine receptors?

A

It stimulates that nicotine receptors

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11
Q

Characteristics of Muscarinic receptors

A

Located in the smooth muscles and myocardium (autonomic or involuntary muscles)

Stimulates by acetylcholine

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12
Q

Characteristics of Nicotinic receptors

A

Located in the skeletal muscles ( somatic or voluntary muscles)

Stimulated by ACh

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13
Q

Is autonomic system involuntary or voluntary?

A

Involuntary

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14
Q

What are cholinergic side effects.?

A

Excessive muscarinic stimulation

General: Dizziness, poor perfusion to the brain due to low BP

Eye: Blurred vision due to miosis and loss of accommodation ( poor vision) in dim light

Lung: SOB due to bronchonstriction, increase in bronchial secretions

Cardiovascular: bradycardia, dysrythmias which lead to low be and dizziness

Urinary: urgency, frequency

Exocrine glands: hypersalvation

Excessive nicotinic stimulation

Muscle cramps, fasciculation (muscle twitching)

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15
Q

What does acetylcholine do to the brain?

A

Stimulates the brain

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16
Q

What happens when there is excessive acetylcholine in the central nervous system?

A

Excitation, seizure

17
Q

What is the reversal agent or anti cholinergic drug called?

A

Atropine

18
Q

Reasons to not give cholinergic drugs (contraindication)

A

Pregnancy / lactation

GI obstruction (abdominal pain)

GU obstruction (ureter/ urethra stone)

19
Q

Caution reasons for cholinergic drugs

A

Seizure
Asthma
PUD (peptic ulcer disease) ( when you take cholinergic hydrochloric acid secretions increase)
Bradycardia and Low BP

20
Q

What do cholinergic drugs do?

A

Stimulate the receptor sites for acetylcholine

21
Q

What do Anticholinergic drugs do?

A

Suppresses/blocks receptor sites for acetylcholine

Inhibits action of acetylcholine

22
Q

Anticholinergic side effects

A

GI: decrease secretions , hypoactive bowel sounds

Eye: mydriasis , decrease accommodation in bright light (photophobia)

Heart: increase heart rate and BP

Lungs: bronchodilation , decrease bronchosecretions ,

GU: relax muscle , increase sphincter constriction ( urinary retention)

CNS: drowsiness, decrease tremors

Used to reverse cholinergic

23
Q

Peripheral

A

Outside the brain and spinal cord

24
Q

Autonomic (visceral)

A

Involuntary, acts on smooth muscle and organs

25
Q

Somatic

A

Voluntary, innervates skeletal muscles

26
Q

Central nervous system consists of

A

The brain and spinal cord

27
Q

Adrenergic receptors

Alpha 1. ( Bear )

A

Blood vessels, eye, bladder, prostate

What does it do :

peripheral vasoconstriction will increase BP

Mydriasis (eye dilation )

Urinary retention

28
Q

Adrenergic receptors

Alpha 2 (sleepy chicken )

A

What does it do:

Prevents norepinephrine release

Promotes vasodilation which decreases BP

Miosis

29
Q

Adrenergic receptor

Beta 1

A

Location: heart, blood vessels

What does it do: Increased heart rate and cardiac output

30
Q

Adrenergic receptor

Beta 2

A

Location: Lung

What does it do: Bronchodilation

31
Q

Adrenergic receptors

Dopaminergic

A

Location: kidney, mesentery, coronary

Only works with dopamine

What does it do: increases contractility of myocardium , diuresis and natriuresis, increased circulation to mesentery, coronary artery and cerebral artery

32
Q

Selective drugs

A

Works on specific receptors A1, A2, B1,B2

Albuterol is a selective beta 2 agonist

Opens airways, helps asthma and COPD

At higher dose becomes non selective and stimulating beta 1 can cause tachycardia

33
Q

Non selective drugs

A

Effects different receptors at the same time, activates alpha 1, beta 1 and 2

Increases BP and HR , opens airway

Epinephrine

34
Q

Do not give Adergernic “bear drugs” to people with

A

Glaucoma

BPH

35
Q

Adrenergic blockers can work in what two ways?

A

Directly by occupying receptors
- Block effects of Adrenergic neurotransmitter

Indirectly by inhibiting telecast of neurotransmitters (epi and norepinephrine)
- Block alpha and beta receptor sites

36
Q

Adrenergic effects (bear)

A 
Bronchodilation
Mydriasis
Increase heart rate 
Peripheral vasoconstriction 
Shunting from GI, GU, Skin
Increase BP 
Decrease secretions
Decrease GI motility
Increase coagulability
Bladder relaxes, sphincter/ prostate closes
Uterus relaxes 
Glycogen Lysis
37
Q

Cholinergic effects (sleepy chicken)

A 
Bronchoconstriction
Myosis
Decrease Heart rate
Peripheral vasodilation 
Increase circulation to GI,GU,Skin 
Decrease BP
Increase secretions 
Increase GI motility 
Normal coaguability 
Bladder contracts, bladder spinchter/prostate open 
Uterus contracts 
Glycerin synthesis
38
Q

What will acetylcholine do the peripheral nervous system

A

Acetylcholine will rest and digest ( sleepy chicken) on peripheral nervous system but will stimulate the brain

Pharm (19 decks)

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