Pain- PDN Patho

Question 1

How does PDN occur?

Answer 1

to peripheral nerves → hyperexcitability, spontaneous impulses within axon and dorsal root ganglion of these peripheral nerves

Question 2

In PDN, there are _____ electrical connections

Answer 2

Abnormal

Question 3

In PDN, what is coupled and released?

Answer 3

Sympathetic and afferent neurons are coupled and there’s an abnormal release of substance P from A fibers

Question 4

Persistent nerve stimulation activates _____ located ____

Answer 4

It activates NMDA receptors located postsynaptically in the dorsal horn