Pain- PDN Patho Flashcards

1
Q

How does PDN occur?

A

to peripheral nerves → hyperexcitability, spontaneous impulses within axon and dorsal root ganglion of these peripheral nerves

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2
Q

In PDN, there are _____ electrical connections

A

Abnormal

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3
Q

In PDN, what is coupled and released?

A

Sympathetic and afferent neurons are coupled and there’s an abnormal release of substance P from A fibers

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4
Q

Persistent nerve stimulation activates _____ located ____

A

It activates NMDA receptors located postsynaptically in the dorsal horn

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