Pain- PDN Patho Flashcards
1
Q
How does PDN occur?
A
to peripheral nerves → hyperexcitability, spontaneous impulses within axon and dorsal root ganglion of these peripheral nerves
2
Q
In PDN, there are _____ electrical connections
A
Abnormal
3
Q
In PDN, what is coupled and released?
A
Sympathetic and afferent neurons are coupled and there’s an abnormal release of substance P from A fibers
4
Q
Persistent nerve stimulation activates _____ located ____
A
It activates NMDA receptors located postsynaptically in the dorsal horn