Pain- Opioid Analgesics DI

Question 1

Opioid analgesics used in pain

Answer 1

Tramadol, tapentadol

Question 2

Tramadol indications

Answer 2

Off-label for PDN and PHN

Question 3

Tapentadol indication

Answer 3

PDN

Question 4

Tramadol MoA

Answer 4

Weak mu agonist –> inhibits the reuptake of NE and serotonin in the CNS

Question 5

MoA of tramadol’s metabolite

Answer 5

Also a mu agonist

Question 6

MoA of tapentadol

Answer 6

Mu agonist
NE reuptake inhibition
Weak anticholinergic effects

Question 7

Pros of tramadol

Answer 7

Good for moderate pain
Less respiratory depression and abuse potential

Question 8

ADEs of tramadol

Answer 8

Dizziness, GI effects, constipation, seizure risk

Question 9

Tramadol DDIs

Answer 9

CBZ, quinidine, TCAs, SSRIs

Question 10

What is tramadol useful for?

Answer 10

Patients with nociceptive and neuropathic pain

Question 11

Does tapentadol have active metabolites?

Answer 11

No

Question 12

Tapentadol control schedule

Answer 12

CII

Question 13

Tapentadol clinical pearl

Answer 13

Can repeat the dose once 1 hour after the first dose (“first dose load”)