ADHD- AMP DI/Clinical Pearls Flashcards
AMP is the preferred stimulant in what population?
Adults
AMP MoA
Increases release of DA and NE into the synapse from the presynaptic nerve terminal –> enhances release of NE in the periphery
High doses of AMPs will result in what?
Serotonin release and acts like a serotonin agonist
AMPs and high fat meals
Delay the time to peak concentration
AMP dosing
Titrate weekly until clinical response
IR formulations of AMPs must be dosed how often?
At least BID
IR formulations are preferred for what patient population?
Kids <5 years old
The afternoon dose of AMPs shouldn’t be given how soon before bedtime?
<6 hours
AMP CI
CVD history
Clinical pearls: mixed AMP-IR salts and AMP sulfate IR
Approved in kids ≥3 years old
Clinical pearls: mixed AMP-XR salts
50% IR, 50% ER
Can open and put over applesauce
Clinical pearls: amphetamine sulfate XR solution (Dyanavel XR)
Dose conversion is NOT 1:1 and needs retitration when switching
Dyanavel XR is approved in what age group?
≥6 years old
Dyanavel XR ADEs
Epistaxis, upper abdominal pain, allergic rhinitis
Clinical pearls: AMP sulfate XR-ODT and ER suspension (Adzenys XR-ODT, Adzenys ER)
Dose conversion isn’t 1:1 when switching agents
Can take with or without food
Don’t chew the ODT tablet
Adzenys is approved in what age group?
≥6
Taking food with Adzenys does what to the serum peak?
Delays it by 2 hours
Clinical pearls: AMP sulfate XR (Mydayis)
Can’t convert mg-to-mg with other AMPs
Has a triple time release bead system within the capsule to reduce medication wearing off
Mydayis is approved in what age group?
≥13 years old
Clinical pearl: lisdexamfetamine
Designed for less abuse potential
