ADHD- AMP DI/Clinical Pearls

Question 1

AMP is the preferred stimulant in what population?

Answer 1

Adults

Question 2

AMP MoA

Answer 2

Increases release of DA and NE into the synapse from the presynaptic nerve terminal –> enhances release of NE in the periphery

Question 3

High doses of AMPs will result in what?

Answer 3

Serotonin release and acts like a serotonin agonist

Question 4

AMPs and high fat meals

Answer 4

Delay the time to peak concentration

Question 5

AMP dosing

Answer 5

Titrate weekly until clinical response

Question 6

IR formulations of AMPs must be dosed how often?

Answer 6

At least BID

Question 7

IR formulations are preferred for what patient population?

Answer 7

Kids <5 years old

Question 8

The afternoon dose of AMPs shouldn’t be given how soon before bedtime?

Answer 8

<6 hours

Question 9

AMP CI

Answer 9

CVD history

Question 10

Clinical pearls: mixed AMP-IR salts and AMP sulfate IR

Answer 10

Approved in kids ≥3 years old

Question 11

Clinical pearls: mixed AMP-XR salts

Answer 11

50% IR, 50% ER
Can open and put over applesauce

Question 12

Clinical pearls: amphetamine sulfate XR solution (Dyanavel XR)

Answer 12

Dose conversion is NOT 1:1 and needs retitration when switching

Question 13

Dyanavel XR is approved in what age group?

Answer 13

≥6 years old

Question 14

Dyanavel XR ADEs

Answer 14

Epistaxis, upper abdominal pain, allergic rhinitis

Question 15

Clinical pearls: AMP sulfate XR-ODT and ER suspension (Adzenys XR-ODT, Adzenys ER)

Answer 15

Dose conversion isn’t 1:1 when switching agents
Can take with or without food
Don’t chew the ODT tablet

Question 16

Adzenys is approved in what age group?

Answer 16

≥6

Question 17

Taking food with Adzenys does what to the serum peak?

Answer 17

Delays it by 2 hours

Question 18

Clinical pearls: AMP sulfate XR (Mydayis)

Answer 18

Can’t convert mg-to-mg with other AMPs
Has a triple time release bead system within the capsule to reduce medication wearing off

Question 19

Mydayis is approved in what age group?

Answer 19

≥13 years old

Question 20

Clinical pearl: lisdexamfetamine

Answer 20

Designed for less abuse potential