ADHD- alpha-Adrenergic Agonists DI

Question 1

Alpha-adrenergic agonist drugs

Answer 1

Clonidine, guanfacine

Question 2

Formulation of clonidine and guanfacine used in ADHD

Answer 2

ER

Question 3

Alpha-adrenergic agonist effects in ADHD

Answer 3

Increase blood flow to the prefrontal cortex to enhance working memory and executive functioning and inhibits NE release

Question 4

Are alpha-adrenergic agonists better than stimulants for ADHD monotherapy

Answer 4

Nope

Question 5

Alpha-adrenergic agonist ADEs

Answer 5

Sedation/dizziness, hypotension, constipation, heart block

Question 6

Clonidine is often used as an adjunct for what sleep problem?

Answer 6

Insomnia

Question 7

ER formulations of clonidine and guanfacine shouldn’t be taken with what?

Answer 7

A high fat meal

Question 8

Onset of effect of alpha-adrenergic agonists

Answer 8

1-2 weeks

Question 9

How many doses do you need to take of ER clonidine?

Answer 9

1-2 (duration is 10-12 hours)

Question 10

How many doses do you need to take of ER guanfacine?

Answer 10

1 (duration is 18 hours)