ADHD- Norepinephrine Reuptake Inhibitors DI

Question 1

NE reuptake inhibitor drugs used in ADHD

Answer 1

Atomoxetine, viloxazine ER

Question 2

NE reuptake inhibitors are safe and effective in what populations?

Answer 2

Children, teens, adults

Question 3

NE reuptake inhibitors MoA

Answer 3

Inhibit presynaptic reuptake of NE

Question 4

Which one has greater efficacy: stimulants or atomoxetine?

Answer 4

Stimulants

Question 5

How should you dose atomoxetine in children?

Answer 5

BID to increase tolerability

Question 6

How many times can you dose atomoxetine a day?

Answer 6

1-2 (duration of effect is 10-12 hours)

Question 7

How many times can you dose viloxazine ER a day?

Answer 7

1 (duration is 24 hours)

Question 8

Onset of effect of NE reuptake inhibitors

Answer 8

1-2 weeks

Question 9

Full benefits of NE reuptake inhibitors aren’t seen until when?

Answer 9

6-8 weeks

Question 10

What may worsen initially with atomoxetine?

Answer 10

Behavior

Question 11

ADEs of NE reuptake inhibitors

Answer 11

Upset stomach, psychiatric, and CV effects (QTc prolongation)

Question 12

NE reuptake inhibitors aren’t recommended in what patients?

Answer 12

Patients with structural heart defects or serious heart problems

Question 13

Risk with long-term use of atomoxetine

Answer 13

Liver toxicity

Question 14

Which NE reuptake inhibitor needs renal dose adjustment?

Answer 14

Viloxazine ER

Question 15

Which NE reuptake inhibitor has a BBW and what is it for?

Answer 15

Atomoxetine, has a BBW for new-onset suicidality

Question 16

NE reuptake inhibitors: both of them have DDIs with these meds

Answer 16

Each other
QTc prolongation with APS, TCAs

Question 17

Atomoxetine-specific DDIs

Answer 17

Increased concentrations by paroxetine and fluoxetine

Question 18

Viloxazine is an inhibitor for what CYP enzymes?

Answer 18

strong 1A2, weak 2D6 and 3A4

Question 19

Viloxazine DDIs: ADs

Answer 19

duloxetine, fluoxetine, paroxetine, venlafaxine, TCAs

Question 20

Viloxazine DDIs: APS

Answer 20

aripiprazole, asenapine, chlorpromazine, clozapine, olanzapine, perphenazine, risperidone, thioridazine

Question 21

Viloxazine DDIs: controlled substances

Answer 21

BZDs
Buprenorphine, hydrocodone, methadone, oxycodone