PAGETS DISEASE

Question 1

chronic skeletal disorder of UN-known origin, characterized by excessive and abnormal remodeling of bone?

considered an MBD?

Answer 1

pagets disease

yes

Question 2

polyostotic or monostotic? (in terms of epidemiology)

Answer 2

polyostotic

Question 3

pain often a result of?

where??***

Answer 3

arthritis
pathologic fx
neurologic or malignant degeneration

hip joint

Question 4

most frequently involved site?

Answer 4

1) spine and proximal femur
2) skull
3) pelvis

Question 5

labs?

Answer 5

elevated alkaline phosphatase

normal serum Ca2+ and PO4- levels

Question 6

what are the 3 progressive phases?

Answer 6

osteolytic phase

mixed lytic sclerotic phase

benign sclerotic phase

Question 7

name this phase?

massive resorption
hypervascular resorption
-blades of grass 
epiphyseal involvement
diaphyseal onset is rare
osteoporosis circumscripta

Answer 7

osteolytic phase

Question 8

name this phase?

new bone formation in areas of prior lysis

cortical thickening and porosity

boney trabeculae may become thickened/coarsened

Answer 8

mixed lytic sclerotic phase

Question 9

name this phase?

end stage
bones thickened
sclerotic, end result:
-thickened internal trabeculae
cotton wool appearance of skull
enlarged picture frame

*hallmark, enlargement and sclerosis (cortical and trabecular thickening)

Answer 9

benign sclerotic phase

Question 10

pedal radiography

calcaneus found in what phase?

Answer 10

mixed lytic sclerotic phase

Question 11

pedal radiography

metatarsals found where?

Answer 11

benign sclerotic phase

Question 12

malignant degeneration causes what?

Answer 12

osteosarcoma

Question 13

secondary osteoarthritis affects?

Answer 13

hips and knees, uniform loss of joint space is typical