HIGH YIELD VIT D DEFICIENCY

Question 1

disease process with deficiency of one or more building blocks necessary for bone mineralization?

Answer 1

Ca2+
PO4-
alkaline phosphatase

Question 2

qualitative and quantitative deficiency in bone assoc. with GI or renal abnormalities/failures,

common denominator?

Answer 2

deficiency of calcium in blood stream

Question 3

general classification?

Answer 3

intestinal rickets or osteomalacia

renal osteomalacia

hypophosphatemia

Question 4

name some intestinal syndromes?

Answer 4

classical vit D deficiencies
idiopathic steatorrhea
chronic pancreatitis

Question 5

this is more commonly found in children causing growth disturbances

what are the two types?

Answer 5

renal syndromes

congenital

• vit D resistant rickets
• fanconis syndrome
• renal tubular acidosis

acquired

• ascending infections of inflammatory pocess
• immune glomerulo tubular nephritis

Question 6

major radiography feature of osteomalacia?

other features?

Answer 6

vit D deficiency so,

incomplete mineralization of normal osteoid tissue-qualitative defect

non specific generalized osteopenia

looser’s zone***

Question 7

DDx?

Answer 7

fibrous dysplasia and paget’s disease

• compressive sides of bones
• remember that pagets disease can occur on convex (tensile) and concave (compressive) surfaces

Question 8

complications of osteomalacia?

Answer 8

fractures and pseudofractures

bowing deformities of long bones

vertebral end plate deformities and/or fractures

basilar invagination-skull