Paeds Flashcards

(271 cards)

1
Q

Nontender abdominal mass associated with high vanillylmandelic acid (VMA) & homovanillic acid (HVA)

A

Neuroblastoma

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2
Q

Most common type of trachoesophageal fistula (TEF)

A

Esophageal atresia with distal TEF (85%)

Unable to pass NG tube

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3
Q

Not contraindication to vaccination

A

Mild illness and/or low grade fever
Current antibiotic therapy
Prematurity

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4
Q

Tests to rule out abusive head trauma

A

Opthalmologic exam, CT & MRI

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5
Q

A neonate has meconium ileus

A

Cystic fibrosis

Hirschprung disease is associated with failure to pass meconium for 48hrs

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6
Q

Bilious emesis within hours after the first breast feeding

A

Duodenal atresia

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7
Q

A 2 month old baby presents with nonbilious projectile emesis. Diagnosis? Management?

A

Pyloric stenosis

Hydrate and correct metabolic abnormalities
Pyloromyotomy to correct pyloric stenosis

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8
Q

Most common primary immunodeficiency

A

Selective IgA deficiency

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9
Q

An infant has high fever and onset of rash as fever breaks. What is he at risk for?

A

Febrile seizures (due to roseola infantum)

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10
Q

A boy has chronic respiratory infections. Nitroblue tetrazolium test negative
What is the immunodeficiency?

A

Chronic granulomatous disease

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11
Q

A child has eczema, thrombocytopenia and high levels of IgA. What is the immunodeficiency?

A

Wiskott-Aldrich syndrome

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12
Q

A 4 month old boy has life-threatening pseudomonas infection. What is the immunodeficiency?

A

Bruton’s X-linked agammaglobulinaemia

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13
Q

What is the acute phase treatment for Kawasaki disease?

A

High dose ASA for inflammation and fever

IVIG to prevent coronary aneurysms

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14
Q

What is the treatment for mild and severe unconjugated hyperbilirubinaemia?

A
Phototherapy (mild)
Exchange transfusion (severe) 

NB: do NOT use phototherapy for conjugated hyperbilirubinaemia!

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15
Q

Sudden onset mental status changes, emesis &a liver dysfunction after ASA intake

A

Reye syndrome

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16
Q

A child has loss of red light reflex (white pupil)
What is the diagnosis?
What cancer is he at increased risk of?

A

Suspect retinoblastoma

Osteosarcoma

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17
Q

6month vaccinations for healthy child

A

Hep B, DTaP, Hib, IPV, PCV, rotavirus

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18
Q

Tanner stage 3 in a 6 year old girl

A

Precocious puberty

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19
Q

Infection of small airways with epidemics in winter & spring

A

RSV bronchiolitis

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20
Q

Cause of neonatal RDS

A

Surfactant deficiency

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21
Q

Red “currant jelly” stools, colicky abdominal pain, bilious vomiting & sausage shaped mass in RUQ

A

Intussusception

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22
Q

A congenital heart disease that cause secondary hypertension. What would you find on physical examination?

A

CoA

Reduced femoral pulses

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23
Q

What is the first line treatment for otitis media?

A

Amoxicillin

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24
Q

What is the most common pathogen causing croup?

A

Parainfluenza virus type 1

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25
A homeless child is small for his age and has peeling skin and a swollen belly
Kwashiorkor (protein malnutrition)
26
Defect in X-linked syndrome with mental retardation, gout, self-mutilation & choreoathetosis
Lesch-Nyhan syndrome (purine salvage problem with HGPRTase deficiency)
27
A newborn girl has a continuous "machinery murmur". What drug would you give?
Indomethacin - given to close the PDA
28
A newborn girl with a posterior neck mass and swelling of the hands
Turner syndrome
29
A young child presents with proximal muscle weakness, waddling gait & pronounced calf muscles
Duchenne muscular dystrophy
30
A first-born female who was born in breech position is found to have an asymmetric skin folds on newborn exam. What is the diagnosis? What is the treatment?
Developmental dysplasia of the hip If severe, consider a Pavlik harness to maintain abduction
31
An 11-year old obese African American boy presents with sudden onset of limp Diagnosis? Work up?
Slipped capital femoral epiphysis AP & frog-leg lateral radiographs
32
An active 13-year old boy has anterior knee pain
Osgood-Schlatter disease
33
Mimics of bruising
Mongolian spots (non -pathological) Coining/cupping (alternative treatments in certain cultures)
34
Pathological bruises on head and torso or patterning
Hit with hand or belt
35
Types of burns presentations:
Contact burns — cigarette /curling iron Immersion burns: —hot water, on buttocks or stocking glove distribution
36
Mimics of burns injury
Scalded skin syndrome OR Severe contact dermatitis
37
Epiphysis/metaphyseal bucket fractures
Spiral humerus/femur fracture
38
Posterior rib fracture indicates?
Indicated squeezing
39
Mimic of fractures
Osteogenesis imperfecta
40
Lethargy, feeding difficulty, apnoea, seizures, retinal haemorrhage, subdural/epidural haematoma
Abusive head trauma
41
Mimic for abusive head trauma
Accidental head trauma
42
Work up for NAI
X-ray skeletal survey and bone scan If suspect sexual: gonorrhoea, syphilis, chlamydia, HIV sperm testing within 72hrs of assault Ophthalmology & non contrast CT for head trauma MRI : white matter changes associated with violent shaking and extent of intra & extracranial bleeds
43
Management for NAI
Document injuries Notify Child Protective Services for possible removal of child from home Hospitalise if necessary to stabilise or protect child
44
True or false: neisseria gonorrhoea isolated on vaginal culture is definitive evidence of sexual abuse.
True
45
True or false: chlamydia trachomatis isolated on vaginal culture is definitive evidence of sexual abuse.
False It can also be acquired from mother during delivery and can persist for up to 3 years
46
Intrauterine risk factors for congenital heart disease
Maternal drug use (EtOH, lithium, thalidomide, phenytoin) Maternal infection (rubella) Maternal illness (DM, PKU)
47
5 cyanotic heart defects (R—>L shunts)
``` Truncus arteriosus TGA Tricuspid atresia TOF TAPVM ``` Only TGA presents with severe cyanosis within the first few hours of life
48
A mother presents with her previously healthy 3 month old infant boy, stating that he has been Increasingly difficult to rouse for the past four hours and has lost interest in feeding; she left the baby alone with her boyfriend while she left the home to run errands. While en route to the hospital, the baby stop breathing. Physical examination is notable for occipital bruising. What is the most likely cause of this child apnoea?
Abusive head trauma This is most common in 3 to 4 month old infants and presents early with non-specific symptoms (lethargy, irritability, poor feeding, vomiting) and later with seizures or apnoea. There is generally no reported history of her trauma. Subdural haematoma and oedema account for most neurological findings. In babies with abusive head trauma, there is a 50 - 70% chance of prior abuse.
49
3 non cyanotic heart defects
VSD, ASD, PDA
50
Most common type and subtype of congenital heart disease
VSD; membranous VSD Most resolve without intervention
51
Murmur found in ASD
Fixed, widely split S2
52
True or false: ASD is an VSD is really present at birth with findings other than harsh systolic murmur
True ASD is VSDs and PDAs are acyanotic conditions and therefore don’t present with cyanosis unless Eisenmenger syndrome has developed
53
Left to right shunt leads to pulmonary hypertension and shunt reversal
Eisenmenger syndrome
54
Condition associated with ASD and endocardial cushion defects
Down syndrome
55
Condition associated with PDA
Congenital rubella
56
Condition associated with coarctation of the aorta
Turner syndrome (many also have bicuspid aortic valve)
57
Condition associated with coronary artery aneurysm
Kawasaki disease
58
Condition associated with congenital heart block
Neonatal lupus
59
Condition associated with Conotruncal abnormalities
TOF(overriding aorta) Truncus arteriosus DiGeorge syndrome (TOF) Velocardiofacial syndrome
60
Apical displacement of the tricuspid valve leaving to atrialisation of the right ventricle
Ebstein abnormality
61
Condition associated with Ebstein abnormality
Maternal lithium use during pregnancy
62
Condition associated with heart failure
Neonatal thyrotoxicosis
63
Condition associated with asymmetric septal hypertrophy and TGA
Maternal diabetes
64
Definition of septal defect
A condition in which an opening in the atrial or ventricular septum and allows blood to flow between the atria and ventricles, leading to left to right shunting. VSD is the most common type of congenital heart disease
65
True or false: small septal defect require treatment
False Most small ASDs/VSDs close spontaneously and do not require treatment
66
True or false: antibiotic prophylaxis is recommended prior to procedures
False
67
Indications for surgical repair in septal defect
Symptomatic patients who fail medical management Children < 1yo With signs of pulmonary hypertension Older children with large defects that have not reduced in size over time
68
Complications of septal defect that are prevented by early correction
Arrhythmias, right ventricular dysfunction, Eisenmenger syndrome
69
Treatment of existing CHF associated with septal defect
Diuretics (initial treatment) Positive inotropes ACE inhibitors
70
Symptoms associated with ASD
Holt- Oram syndrome (absent radii, ASD, first degree heart block) Fetal alcohol syndrome Trisomy 21
71
Syndrome is associated with VSD
Apart syndrome (cranial deformities, fusion of the fingers and toes) ``` Down syndrome Fetal alcohol syndrome TORCH infections Cri du chat syndrome Trisomies 13 and 18 ```
72
Presentation of ASD
Small defects: asymptomatic Large defects: easy fatigability; frequent respiratory infection; FTT
73
Presentation of VSD
Small defects: asymptomatic Large defects: recurrent respiratory infection; dyspnoea; FTT; CHF
74
Auscultation findings in ASD
Wide, Fixed split S2 Systolic injection murmur at the left USB (increased flow across pulmonary valve) Major diastolic rumble at the left LSB
75
Auscultation findings in VSD
Harsh holosystolic murmur at LLSB (louder for small defects) Narrow S2 with loud P2 (large defect) Mid diastolic apical rumble (due to increased flow across mitral valve)
76
Chest x-ray findings in septal defect
Cardiomegaly Increased pulmonary vascular markings
77
ECG findings in ASD
RVH Right atrial enlargement PR prolongation is common
78
ECG findings in VSD
LVH (RVH may also be found with large defects)
79
Echo findings in septal defect
Defect and blood flow across the atrial or ventricular septum
80
Definition of PDA
Failure of the ductus arteriosus to close in the first few days of life, leading to and acyanotic left to right shunt from the aorta to the pulmonary artery.
81
4 things to look for in infants presenting in a shop like state within the first few weeks of life
1. Sepsis 2. Inborn errors of metabolism 3. Ductal dependent congenital heart disease usually left-sided lesions 4. Congenital adrenal hyperplasia
82
Presentation of PDA
Typically asymptomatic Large defects: FTT, recurrent LRTI, clubbing and CHF
83
Examination findings in PDA
Continuous machinery murmur at second left ICS at the sternal border Loud S2 Wide pulse pressure and bounding peripheral pulses
84
Diagnostics test of choice for PDA
Colour flow Doppler echocardiogram
85
Treatment for PDA
Indomethacin (NSAID) for closure unless PDA is needed for survival Surgical closure is required if indomethacin fails or if the child is >6-8 mo
86
Conditions where PDA is needed for survival
TGA, TOF, hypoplastic left heart
87
Contraindication for indomethacin use
Intraventricular haemorrhage
88
Definition and aetiology of CoA
Construction of a portion of the aorta, Leading to increased flow proximal to and decreased flow distal to the coarctation Occurs just distal to the left subclavian artery in 90% of patients Associations: turner syndrome, berry aneurysms, male gender More than 2/3 of patients have a BAV
89
Presentation of CoA
Upper extremity hypertension, Weak femoral pulses Low extremity claudication, syncopes, epistaxis, headache Radio femoral delay, short to systolic murmur in the left axilla, forceful apical impulse Infancy: poor feeding, lethargy, tachypnoea, eventual shock like state when the PDA closes
90
A 2 yo boy is brought to the paediatrician because of shortness of breath and easy fatiguability during play. O/E tachypnoea and a soft holosystolic murmur of the left lower sternal border. What is the most likely cause of the boy’s symptoms?
Large untreated VSD leading to Eisenmenger syndrome There is less turbulence across a large defect compared with a small one leading to a softer murmur
91
Diagnostic workup for CoA
Colour flow Doppler echocardiography CXR younger: cardiomegaly and pulmonary congestion CXR older: 3 sign & rib notching
92
What is 3 sign on CXR?
In CoA Pre-and post dilation of the co-optation segment with aortic wall indentation
93
What is rib notching on CXR?
In CoA Collateral circulation through the intercostal arteries
94
Treatment for CoA
PGE1 to keep ductus arteriosus open (Severe infant) Surgical correction or balloon angioplasty is controversial Monitor for restenosis, aneurysm development, aortic dissection
95
DiGeorge syndrome
CATCH 22 Cardiac abnormalities (TGA) Abnormal facies (retrognathia/micrognathia, long face, short philtrum, low set ears) Thymic aplasia Cleft palate Hypercalcaemia (2/2 parathyroid hypoplasia/a Genesis) 22q11 deletion
96
Most common cyanotic congenital heart lesion in the newborn
TGA
97
Definition of transposition of the great arteries
The aorta is connected to the right ventricle and the pulmonary artery to the left ventricle, creating parallel pulmonary and systemic circulations Without a septal defect and the PDA it is incompatible with life
98
True or false: both septal defect and PDA are needed to sustain life in TGA
True PDA alone is usually not sufficient to allow adequate mixing of blood
99
Risk factors for TGA
Maternal diabetes | DiGeorge syndrome
100
Presentation and examination of TGA
Cyanosis within first few hours of life O/E Tachypnoea, progressive hypoxaemia, extreme sinuses If the VSD is present a systolic murmur may be heard at the left sternal border
101
Egg shaped silhouette on chest x-ray
TGA
102
Diagnostic workup of TGA
Echo CXR: narrow heart base, Absence of main pulmonary artery segment, egg shape silhouette, Increased pulmonary vascular markings
103
Treatment for TGA
IV PGE to maintain or open the PDA Arterial or atrial switch is definitive
104
Indications for balloon atrial septostomy in TGA
Unfeasible surgery in the first few days of life PDA cannot be maintained with prostaglandin
105
Purpose of balloon atrial septostomy
To create or enlarge an ASD in TGA
106
Most common cyanotic congenital heart disease in children
TOF
107
4 components of TOF
RVOTO, Overriding aorta, RVH, VSD
108
Tet spells
TOF Children off and Scott for relief during hypoxaemic episodes which increase systemic vascular resistance, thus increasing bloodflow to the pulmonary vasculature and improved oxygenation
109
Presentation of TOF
Tet spells, FTT, mental status changes O/E: Systolic injection murmur at the left upper sternal border (RVOTO); right ventricular heave; single S2
110
Diagnosis of TOF
Echocardiography and catheterisation
111
Boot shaped heart in CXR
TOF
112
Diagnostic features of TOF
CXR: boot shaped heart & DECREASED pulmonary vascular markings ECG: right axis deviation & RVH N.B: Remember that a VSD resulting in increased pulmonary vascular markings
113
Management of TOF
Severe RVOTO or atresia—> immediate PGE1 & urgent surgical consultation Tet spells —> 02, propranolol, phenylephrine, knee chest position, fluids and morphine Surgery: balloon atrial septostomy (temporary palliation); Blalock-Taussig shunt (definitive)
114
No babbling and all gesturing by 12 months, no two word phrases by 24 months, impaired social interaction, restricted interest, and insistent on routine
Autism
115
Left hand or chest when prone Tracks past midline Alerts to sound; coos Recognises parent; exhibit social smile
2 months
116
Rolls front to back, back to front (four months) Grasps rattle Laughs and squeals; orients to voice; begins to make consonant sounds Enjoys looking around; laughs
4 to 5 months
117
Sits unassisted Transfers objects; demonstrates raking grasp Babbles Demonstrate stranger anxiety
6 months
118
Crawls; cruises; pulls to stand Uses three finger (immature) pincer grasp Says mamma daddy (non-specific); says first word at 11 months Waves bye-bye; please patt a cake
9 to 10 months
119
Walks alone; Throws objects Uses 2 finger (mature) pincer grasp Uses one to 3 words Imitate actions; exhibit separation anxiety; Follows one step command
12 months
120
Walks up and down stairs; jumps Build a tower of six cubes Uses two word phrases Follows to step commands; remove clothes
2 years
121
Rides tricycle; climb stairs with alternating feet Copies circle; Uses utensils Uses three word sentences Brush his teeth with help; washes or dries hands
3 years
122
Hops Copies a cross (Square at 4.5 years) Knows colours and some numbers Exhibit cooperative play; plays board games
4 years
123
Skips; walks backward for long distances Copies a triangle; ties shoelaces; knows left and right; prints letters Uses five word sentences Exhibits domestic role-playing; plays dress up
5 years
124
True or false going on For premature infants lesson two years of age, chronological age must be adjusted for gestational age
True For example, an infant born at seven months gestation. (2 months early) would be expected to perform at 4 month level at the chronological age of six months
125
Infants with FTT will fall off the head circumference, weight and height curves in which order?
Weight, height, head circumference
126
What does an increased head circumference indicate?
Hydrocephalus or tumour Measured routinely in the first two years
127
What does a reduced head circumference indicate?
Microcephaly (E.g. TORCH infections) Measured routinely in the first two years
128
True or false: it is abnormal for infants to lose 5% of their body weight in the first few days
False Infants may lose 5 to 10% of body weight over the first few days but should return to their body weight by 14 days BW doubles by 4 to 5 months Triples by the 1 year Quadruples by 2 years
129
Definition of FTT
Persistent weightLess than the 5th percentile for age or falling off the growth curve (i.e., crossing two major percentile lines on a growth chart)
130
Causes of organic FTT
Due to an underlying medical condition Cystic fibrosis, congenital heart disease, coeliac’ sprue, pyloric stenosis, chronic infection(E.g. HIV), GORD
131
Causes of non-organic FTT
Primarily due to psychosocial factors Poverty, inaccurate mixing of formula (too much water mixed in), maternal depression, neglect or abuse
132
Management of neglect or severe malnourishment
Children should be hospitalised Calorie counts & Supplemental nutrition if breastfeeding is inadequate
133
Order of Tanner stages of sexual development in girls
Thelarche —> Pubarche —> growth spurt —> menarche
134
Order of Tanner stages for sexual development in boys
Gonadarche —> Pubarche —> adrenarche —> Growth spurt
135
Age of precocious puberty in girls
< 8 years
136
Age of precocious puberty in boys
< 9 years
137
Age of delayed puberty in girls
> 13 years
138
Age of delayed puberty in boys
> 14 years
139
Average age of puberty in girls
10.5 years
140
Average age of menarche in US girls
12.5 years
141
Average age of puberty in boys
11.5 years
142
Any sign of secondary sexual maturation in girls < 8 years or boys < 9 years of age. Orphan idiopathic; maybe central or peripheral
Precocious puberty
143
No testicular enlargement in boys by age 14, or no breast development or pubic hair in girls by age 13
Delayed puberty
144
A normal variant, and the most common cause of delayed puberty The growth curve legs behind others of the same age but remains consistent There is often a positive family history, and children ultimately achieve target height potential
Constitutional growth delay
145
Causes of pathological puberty delay
Systemic disease (e.g. IBD) Malnutrition (e.g. anorexia nervosa) Gonadal dysgenesis (e.g. Klinefelter syndrome, turner syndrome) Endocrine abnormalities (e.g. hyperpituitarism, hypothyroidism, Kallmann syndrome, androgen insensitivity syndrome, Prader Willi syndrome)
146
Trisomy 21 As a result of meiotic nondisjunction (95%), Robertsonian translocation(4%), or mosaicism (1%)
Down syndrome
147
Trisomy 18
Edwards syndrome
148
Trisomy 13
Patau Syndrome
149
The most common chromosomal disorder and cause of intellectual disability
Down syndrome
150
Trisomy associated with advanced maternal age
Down syndrome
151
Intellectual disabilities, flat facial profile, up slanted eyes with epicanthal folds, single palmar crease, general hypotonia, and extra neck folds (nuchal folds are sometimes seen on prenatal ultrasound)
Down syndrome
152
Associated with atlantoaxial instability, duodenal atresia, Hirschprungs disease & congenital heart disease
Down syndrome
153
Most common cardiac malformations in Down’s syndrome
AV canal (60%); ASDs, VSDs, and PDAs(20%), complex congenital heart disease
154
Trisomy associated with an increased risk of ALL, Hypothyroidism, and early onset Alzheimer’s disease
Down syndrome
155
Trisomy presenting with severe intellectual disabilities, rocker bottom feet, low set ears, micrognathia, clenched hands (Overlapping fourth and fifth digits), prominent occiput Death usually occurs within one year of birth
Edwards syndrome
156
Associations of Edward syndrome
Congenital heart disease; horseshoe kidneys
157
Trisomy presenting with severe intellectual disabilities, microphthalmia, microcephaly, Cleft lip and palate, holoprosencephaly, punched out scalp lesions, Polydactyly, omphalocele Death usually occurs within one year of birth
Patau syndrome
158
47, XXY in males Associated with advanced maternal age
Klinefelter syndrome Characterised by the presence of an activated X chromosome (Barr body)
159
One of the most common causes of hypogonadism in males
Klinefelter syndrome
160
Presents with testicular atrophy, Eunuchoid body shape, tall stature, long extremities, gynaecomastia, female hair distribution
Klinefelter syndrome
161
Treatment of Klinefelter syndrome
Testosterone Prevents gynaecomastia; improves secondary sexual characteristics
162
45, XO in females Not associated with advanced maternal age
Turner syndrome Missing 1 X chromosome; no Barr body
163
Most common cause of primary amenorrhoea
Turner syndrome Due to ovarian dysgenesis (treat with oestrogen)
164
Short stature, shield chest, widely spaced nipples, webbed neck, CoA (weak femoral pulses), And or BAV
Turner syndrome Represented lymphoedema of the hands and feet in the neonatal period May have horseshoe kidney
165
47, XYY Observed with increased frequency among inmates of penal institutions
Double Y males
166
Patients often look normal; some patients are very tall with severe acne (seen in 1 to 2% of XYY male patients)
Double Y males
167
Mode of inheritance of PKU
Autosomal recessive PKU is screened for at birth
168
Aetiology of PKU
Decreased phenylalanine hydroxylase or decreased tetrahydrobiopterin cofactor Tyrosine becomes essential, and phenylalanine accumulates and it is subsequently converted it to its ketone metabolites
169
Normal at birth First few months of life presents with intellectual disabilities, fair hair and skin, Eczema, blond hair, blue eyes, Musty odour in urine
PKU Associated with high risk of heart disease
170
Management of pique you
Reduce dietary phenylalanine (Artificial sweeteners) & Increased dietary tyrosine Mother with PKU who wants to become pregnant must restrict her diet as above before conception
171
Mode of inheritance of fragile X syndrome
X linked dominant
172
Aetiology of fragile X syndrome
Caused by defect affecting the methylation and expression of the FMR1 gene; A triplet repeat disorder that may show genetic anticipation
173
Second most common genetic cause of intellectual disabilities
Fragile X syndrome
174
Large jaw, Large testes and large ears with autistic behaviours
Fragile X syndrome
175
Mode of inheritance of Fabry disease
X linked recessive
176
Aetiology of Fabry disease
Caused by a deficiency of alpha galactosidase A that leads to accumulation of ceramide trihexoside in the heart, brain and kidneys
177
Severe neuropathic limb pain (or joint swelling); angiokeratomas and telangiectasias Renal failure and an increased risk of stroke and MI (Thromboembolic events)
Fabry disease
178
The first sign of Fabry disease
Severe neuropathic limb pain
179
Mode of inheritance of Krabbe disease
Autosomal recessive
180
Aetiology of a Krabbe disease
Absence of galactosylceramide and galactoside (due to galactosylceramidase deficiency), leading to the accumulation of galactocerebroside in the brain
181
Progressive CNS degeneration, optic atrophy, Spasticity, and death within the first three years of life
Krabbe disease
182
Mode of inheritance of Gaucher’s disease
Autosomal recessive
183
Aetiology of Gaucher disease
Deficiency of glucocerebrosidase (also known as acid beta glucosidase) that leads to the accumulation of glucocerebroside in the brain, liver, spleen, and bone marrow
184
Crinkled paper appearance with enlarged cytoplasm
Gaucher cells
185
Anaemia and thrombocytopenia Infantile form: early, rapid neurological decline Adult (more common): Compatible with a normal lifespan and does not affect the brain
Gaucher’s disease
186
Mode of inheritance of Niemann- Pick disease
Autosomal recessive
187
Aetiology of Niemann Pick disease
No man PICKS his nose with his sphinger! Deficiency of sphingomyelinase that leads to the buildup of sphingomyelin cholesterol in reticuloendothelial and parenchymal cells and tissues
188
Cherry red spot and hepatosplenomegaly Patients with type A die by age 3
Niemann Pick disease
189
Mode of inheritance of Tay-Sachs disease
Autosomal recessive
190
Aetiology of Tay-Sachs disease
Absence of hexosaminidase leading to GM2 ganglioside accumulation Tay-SaX lacks heXosaminidase!
191
Infants may appear normal until 3 to 6 months of age, when weakness begins and development slows and regresses. An exaggerated startle response may be seen. Cherry red spot but NO hepato-splenomegaly
Tay-Sachs disease
192
Carrier rate 1 in 30 Jews of European descent(One in 300for others) Death occurs by age 3
Tay-Sachs disease
193
Mode of inheritance of metachromatic leucodystrophy
Autosomal recessive
194
Aetiology of metachromatic leucodystrophy
Deficiency of arylsulfatase A lead to an accumulation of sulphatide in the brain, kidney, liver, and peripheral nerves
195
Demyelination leading to progressive ataxia and dementia
Metachromatic leukodystrophy
196
Mode of inheritance of Hurler syndrome
Autosomal recessive
197
Corneal clouding, intellectual disabilities, and gargoylism
Hurler syndrome (a-L-iduronidase deficiency)
198
Mode of inheritance of Hunter syndrome
X linked recessive
199
Aetiology of Hunter syndrome
Iduronate sulphatase deficiency
200
Mild form of Hurler Syndrome with no corneal clouding and mild intellectual disabilities
Hunter syndrome Hunters need to see (no corneal cloud in) to aim for the X!
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True or false: almost all cases of meconium ileus are due to cystic fibrosis
True
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Mode of inheritance of cystic fibrosis
Autosomal recessive
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Aetiology of cystic fibrosis
Mutations in the CFTR gene (chloride channel) on Chr7 and characterised by widespread exocrine gland dysfunction
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Most common severe genetic disease in the United States and most frequently found in whites
Cystic fibrosis
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Neonates presenting with obstruction of the distal ileum due to abnormally thick meconium
Cystic fibrosis
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Presentation of cystic fibrosis in patients under one years
Cough, wheezing, recurrent respiratory infections May also have steatorrhea and or FTT
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Presentation of cystic fibrosis in patients older than one year
FTT (due to pancreatic insufficiency) OR Chronic sinopulmonary disease or sputum production
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Typical recurrent pulmonary infections in cystic fibrosis patients
Pseudomonas Staph aureus
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Most common pulmonary symptom in cystic fibrosis
Chronic cough
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Respiratory symptx in CF
Digital clubbing, chronic cough, dyspnoea, bronchiectasis, haemoptysis, chronic sinusitis, rhonchi, rales, Hyperresonance to percussion, nasal polyposis
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Symptoms of pancreatic insufficiency in CF
Greasy stools, Flatulence Pancreatitis, rectal prolapse, Hypoproteinaemia, biliary cirrhosis, jaundice, oesophageal varices
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Additional atypical symptoms of cystic fibrosis
T2DM, salty tasting skin, male infertility (agenesis of the vas deferens ), unexplained hyponatraemia
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Vitamin deficiency in cystic fibrosis
Vitamins A, D, E, K Secondary to malabsorption and they present with manifestations of these deficiencies (i.e., Nightblindness, Ricketts, neuropathy, coagulopathy)
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Diagnosis of cystic fibrosis
Sweat chloride test (pilocarpine electrophoresis) Genetic testing for confirmation Most states now perform mandatory newborn screening
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Treatment and management of cystic fibrosis
Chest physical therapy, bronchodilators, corticosteroids for pulmonary manifestations Antibiotics to cover pseudomonas and DNase Pancreatic enzymes and fat-soluble vitamins for malabsorption High calorie and high protein diet Lung or pancreas transplants for those with severe disease who can tolerate surgery
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Definition of intussusception
Portion of the bowel invaginates or telescopes into an adjacent segment, usually proximal to the ileocecal valve
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Most common cause of balance traction and children between six months and three years
Intussusception
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Risk factors for intussusception
Meckels diverticulum; Intestinal lymphoma (>6 yrs); Submucosal haematoma (HSP); Polyps; CF (lead point is inspissated stool) Antecedent GI or URI Is seen in many children, which may cause formation of a lead point trough enlargement of Peyer patches
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Classic triad of intussusception (only 1/3 pts)
Severe of abdo pain; Vomiting (initially non-bilious then bilious); currant jelly stool (bloody mucus in stool)
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Abdominal tenderness, positive stool guaiac, Palpable sausage shaped RUQ abdominal mass, empty RLQ on palpation (Dance sign)
Intussusception
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Diagnosis of intussusception
Target sign on USS(During painful episode) AXR:‘s small bowel obstruction, Perforation, soft tissue mass
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Management of intussusception
Correct volume/electrolytes; CBC for leucocytosis, NG tube for decompression Air insufflation enema (if high clinical suspicion)
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Indications for surgical reception in intussusception
Peritoneal signs, unsuccessful enema reduction, Identification of a pathological lead point
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Which is the preferred diagnostic method, barium contrast enema or air insufflation enema?
Air insufflation enema Preferred over water or barium contrast enema for diagnosis and management of intussusception, as it is faster and carries a low risk of complications
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Most common cause of GI tract obstruction in infancy
Pyloric stenosis Nearly all cases are diagnosed between three and 12 weeks of age
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Definition of pyloric stenosis
Hypertrophy of the pyloric sphincter, leading to gastric outlet obstruction More common in first born infant boys
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Associations in pyloric stenosis
Tracheoesophageal fistula, Formula feeding, maternal erythromycin ingestion
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Non-bilious emesis typically beginning around 3 to 5 weeks of age progressing to projectile emesis after most or all feeding
Pyloric stenosis Infants are generally hungry after episodes of vomiting; they initially said feed well but eventually suffer from dehydration and malnutrition
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Palpable olive shaped, mobile, non-tender epigastric mass and visible gastric peristaltic waves
Pyloric stenosis
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Diagnosis of pyloric stenosis
Thickened, elongated pylorus on USS Hypochloraemic, hypokalaemic metabolic alkalosis (loss of HCL and RAAS activation from emesis) String sign (narrow pyloric channel on barium studies)
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Management of pyloric stenosis
NPO, IV access, correct dehydration and acid base or electrolyte abnormalities Definitive surgical management (pyloromyotomy)
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A three-year-old boy born at 39 weeks gestational age via normal spontaneous vaginal delivery has failed to pass meconium and today displays abdominal distension and five episodes of non-bilious vomiting. Rectal exam shows no stool in the rectal vault. Air contrast enema shows an obstruction at the ileum.What is the most likely cause of this patient symptoms?
This infant most likely has meconium ileus resulting from cystic fibrosis However, Hirschsprung’s disease should remain on the differential diagnosis, as it also can cause delayed meconium passage. Meconium ileus causes obstruction of the level of the ileum, whereas Hirschsprung’s disease causes rectosigmoid obstruction and rectal exam may result in the expulsion of stool.
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Most common complication of Meckel diverticulum
Bleeding It may be minimal, or severe enough to cause haemorrhagic shock
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Meckel’s rule of 2s
``` Affects 2% of the population 2% symptomatic by age 2 2X more common in boys 2 tissues (Gastric and pancreatic) 2 inches long Within 2 feet of the ileocecal valve ```
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Definition of Meckel’s diverticulum
Failure of the omphalomesenteric (or vitelline) duct to obliterate, resulting in the formation o a true diverticulum (containing all 3 layers of the intestine) The heterotopia gastric tissue present in most Meckels diverticula causes intestinal ulceration and painless haematochezia
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Most common congenital abnormality of the small intestines affecting up to 2% of children
Meckel’s diverticulum Boys more than girls Most frequently symptomatic in children under two years of age
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Asymptomatic with an incidental finding of painless rectal bleeding
Meckels diverticulum
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Complications of Meckel’s diverticulum
Intestinal perforation or obstruction, diverticulitis (which can mimic acute appendicitis), intussusception
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Diagnostic test of choice for Meckel’s diverticulum
Meckel scintigraphy scan | Tn-99m pertechnetate detects ectopic gastric tissue
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Treatment of Meckel’s diverticulum
Surgical excision of the diverticulum together with the adjacent ileal segment ``` Indications for urgent surgery: – haemorrhage – divericulitis – intestinal perforation – obstruction or intussusception ```
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Definition of Hirschsprung’s disease
Congenital lack of ganglion cells in the distal colon, leading to decreased motility due to unopposed smooth muscle tone in the absence of enteric relaxing reflexes and uncoordinated peristalsis
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Associated diseases to Hirschsprung’s disease
Male gender, down syndrome, Waardenburg syndrome, MEN2
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Neonate presenting with failure to pass meconium within 48 hours of birth, accompanied by bilious vomiting and FTT
Hirschsprung’s disease
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Examination findings in Hirschsprung’s disease
Explosive faecal discharge following DRE Abdominal distension, lack of stool in the rectum, abnormal sphincter tone
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Imaging study of choice for Hirschsprung’s disease
Barium enema Reveals a narrow distal colon with proximal dilation AXR Reveals distended bowel loops with the paucity of air in the rectum Anorectal manometry: The text failure of the internal sphincter to relax after distension of the rectal lumen (atypical presentation) Rectal biopsy for confirmation
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Definitive diagnostic test for Hirschsprung’s disease
Rectal biopsy Confirms the diagnosis and reveals absence of the myenteric (Auerbach) plexus and submucosal (Meissner) plexus along with hypertrophied nerve trunks enhanced with acetylcholinesterase stain
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Surgical treatment of Hirschsprung’s disease
2 stage surgical repair: – Immediate creation of a diverting colostomy – definitive pull through procedure connecting the remaining colon to the rectum few weeks later
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A three week old ex-term infant boy is brought to the ED after experiencing vomiting of increasing frequency and intensity for the past week. His parents state that he now vomits forcefully after every meal and enthusiastically attempts to eat immediately after vomiting. The infant appears lethargic, with sunken fontanelles and decreased skin turgor. The abdomen is soft, non-tender, and non distended; no masses of felt. What is the most likely cause of this infant symptoms?
Pyloric stenosis An obstruction of the gastric outlet secondary to hypertrophy and hyperplasia of the muscle layers of the pylorus. Note that most (60 to 80%) but not all infants present with an olive shaped abdominal mass
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Definition of malrotation with volvulus
Congenital malrotation of the midgut results and abnormal positioning of the small intestine (caecum in the right hypochondrium) and formation of fibrous bands (Ladd bands), which predisposed to obstruction and constriction of bloodflow
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Three week old neonate with bilious emesis, crampy abdominal pain, distension, and positive blood or mucus in the stool
Malrotation with volvulus
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Abdominal x-ray findings in malrotation of the volvulus
Bird beak appearance and air fluid levels
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Investigation of choice in malrotation with volvulus
Upper GI series If the patient is stable and shows an abnormal location of the ligament of Treitz. Ultrasound may be used, but is sensitivity is contingent on the experience of the ultrasonographer.
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Management of malrotation with volvulus
NG tube to decompress intestines, IV fluid hydration Surgical repair (gastric); surgery or endoscopy (intestinal)
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Definition of necrotising enterocolitis
A portion of the bowel (most commonly terminal ileum/proximal colon) undergoes necrosis
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Most common GI emergency in neonates
NEC
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Risk factors for NEC
Low-birth-weight, hypotension, enteral feeding (especially formula)
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One week old with feeding intolerance, delayed gastric emptying, abdominal distension, and bloody stools
NEC
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Complications of NEC
Intestinal perforation, peritonitis, abdominal erythema, and shock; Intestinal strictures; short bowel syndrome
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Pathognomonic for NEC in neonates
Pneumatosis intestinalis on plain films
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Imaging modality of choice in NEC
Plain AXR showing dilated bowel oops, pneumatosis intestinalis (intramural air bubbles representing gas produced by bacteria within the bowel wall), Portal venous gas, or abdominal free air (in the case of bowel perforation) Serial abdominal pain film should be taken every six hours USS may be also be helpful in discerning free air, areas of loculation, and bowel necrosis
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Management of NEC
Supportive: NPO, Orogastric tube for gastric decompression, correct dehydration and electrolyte, TPN, IV Abx Surgery– Ileostomy with mucous fistula later reanastomosis
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Indications for surgery in the NEC
Perforation (free air under the diaphragm)Or worsening radiographic signs on serial abdominal plain films
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B cells or T cells: Make immunoglobulins and are responsible for immunity against extra cellular bacteria
B cells
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B cells or T cells: Responsible for immunity against intracellular bacteria, viruses, and fungi
T cells
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Name the B-cell disorders
Bruton agammaglobulinaemia Common variable immuno deficiency (CVID) IgA deficiency
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Name the T-cell disorders
Thymic aplasia (DiGeorge syndrome)
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Name of the combined b-cell T-cell disorders
Ataxia-telangiectasia SCID Wiskott-Aldrich syndrome
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Name the phagocytic deficiencies
Chronic granulomatous disease (CGD) Leucocyte adhesion deficiency Chédak-Higashi syndrome Job syndrome (hyper immunoglobulin E syndrome)
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Name the compliment disorders
C1 esterase inhibitor deficiency (hereditary angioedema) Terminal complements deficiency (C5-9)
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Untreated Kawasaki disease can lead to _________ in up to 25% of patients
Coronary aneurysms
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Newborn presents with lymphoedema of the hands and feet, weak femoral pulses, webbed neck, widely spaced nipples, short 4th metacarpals, and nail dysplasia. What form of hormone replacement therapy will the child need in the future?
Oestrogen replacement therapy is required for ovarian dysgenesis Without exogenous oestrogen, this child will be at increased risk of delayed puberty and osteoporosis later in life