oxidative phosphorylation Flashcards
how does NADH from the cytoplasm get in through the membrane
malate aspartate shuttle
decribe the malate aspartate shuttle
- NADH from glycolysis is used to generate malate from oxaloacetate in cytosol
- Malate transporters transfer malate to mitochondrial matrix.
- Malate conversion to
oxaloacetate in TCA cycle
generates NADH in addition to the malate that arises from Fumarate
what does succinte dehydrogenase generate
fumarate and FADH2
what is phosphoryl transport potential of ATP measured by
free energy change
what is electron transfer potential of NADH and FADH2 measured by
redox potential
what is redox potential
The standard redox potential E’o of a (reduced) substance X is a measure for how readily X donates an electron (in comparison with H2)
what does a negative Eo mean
reduced form of X has a lower affinity for electrons than H2, a positive E’o means the opposite
negative means they will donate them
what will things with positive Eo tend to do
accept electrons - higher affinity for them than H2
what complex doesnt pump protons
II
where do electrons form NADH enter the resp chain
complex I
where do electrons from FADH2 enter the resp chain
complex II
what is complex II part of
the TCA cycle
what do electrons ultimately do
transferred onto O2 to form H2O
what are cytochromes
proteins that contain a haem group as a functional co factor
what does haem contain
a Fe(II) ion that can take up and release electrons
