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RB Y1 Principles > antibiotic mechanisms > Flashcards

antibiotic mechanisms Flashcards

1
Q

cell wall synthesis - peptidoglycan cross linking

A

penicillin cephalosporin carbapenem (ß-lactams)

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2
Q

cell wall synthesis - peptidoglycan synthesis

A

glycopeptide

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3
Q

proteins synthesis - 50s subunit

A

macrolide

chloramphenicol

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4
Q

protein synthesis - 30s subunit

A

tetracycline aminoglycoside

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5
Q

what is vancomycin

A

glycopeptide

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6
Q

name an amino glycoside

A

gentamicin

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7
Q

name a fluoroquinolone

A

ciprofloxacin

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8
Q

folic acid synthesis

A

sulphonamide trimethoprim

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9
Q

rna polymerase

A

rifampicin

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10
Q

dna topoisomerase

A

fluoroquinolone

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11
Q

damage dna

A

metronidazole

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12
Q

what are the 4 Ds of antimicrobial stewardship

A

drug duration deescalation dose

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13
Q

what is pseudominas treated with

A

ciprofloxacin

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14
Q

Neissera meningitides

A

gram negative diplococci

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15
Q

pseudomonas

A

gram negative rod shaped bacterium

strict aerobe

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16
Q

syphillis

A

treponema pallidum - spriochaete

17
Q

beta lactam antibiotics

A
  • pencillin
  • cephalosporins
  • carbapenems

Bacteria often develop resistance to beta-lactam antibiotics by synthesizing a beta-lactamase. To overcome this resistance, beta-lactam antibiotics are given with beta-lactamase inhibitors such as clavulanic acid

18
Q

penicillins

A
  • penicillin - narrow spectrum (positive)
  • amoxcillin and co-amoxiclav (negative and positive)
  • temocillin (negative)
19
Q

side effects of ciprfloxacin

A

tendonitis

20
Q

gram negative cover

A

gentamicin

aztreonam if contraindicated

21
Q

anaerobic cover

A

metronidazole

22
Q

C diff causing ABx

A
  • Ciprofloxacin (fluoroquinolones), Clindamycin, Cephalosporins (Ceftriaxone) and Co-Amoxiclav kill off the normal gut bacteria and allow the overgrowth of C. Diff, which causes a nasty gastroenteritis
23
Q

non/lactose fermenter Enterobacteriaceae

A

lactose fermenter:

  • E coli,Klebsiella, Enterobacter

non-lactose:

  • salmonella, proteus

RB Y1 Principles (16 decks)

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