Other Antiprotozoal Drugs Flashcards
Blocks dihydropteroate synthase
Sulfamethoxazole
Sulfadiazine
Drugs for pneumocystosis and toxoplasmosis
Cotri
Pentamidine
Pyrethamine-Sulfadiazine
Blocks dihydrofolate reductase
Timethoprim
Pyrimethamine
DOC for prophylaxis and treatment of pneumocystosis
Cotri
Backup for prophulais and treatment of pneumocystosis
Pentamidine
DOC for prophylaxis and treatment of toxoplasmosis
Pyrimethamine-sulfadiazine
Prophylaxis for T. gondii and isospora belli
Cotri
Mode of administration of pentamidine
Aerosol/nasal spray
SE: hematotoxicity (what kind?)
Pyrimethamine-sulfadiazine (megaloblastic anemia, thrombocytopenia)
Displaces protein binding of other drugs
Cotri
Drugs for West African sleeping sickness
Early: Pentamidine
CNS: Eflornithine
Drugs for East African sleeping sickness
Early: Suramin
CNS: Melarsoprol
Drugs for trypanosomiasis that cross the BBB
Melarsoprol
Eflornithine
Drugs for trypanosomiasis that do not cross the BBB
Suramin
Pentamidine
Used for kala-azar
Pentamidine
Back up drug for onchocerciasis
Suramin
Compare eflornithine and melarsoprol in terms of toxicity
Melarsoprol»eflornithine
Suicide inhibitor of ornihine decarboxylase
Eflornithine
Organic arsenical. Inhibits enzyme sulfhydryl groups in trypanosomes
Melarsoprol
Inhibits trypanothione reductase
Nifurtimox
DOC for leishmaniasis
Sodium stinogluconate (except in India - amphotericin B)
Causes anemia, neutropenia, hepatitis, pancreatitis
Pentamidine
Causes hemolytic anemia and agranulocytosis
Suramin
Causes reactive encephalopathy
Melarsoprol
Causes cardiotoxicity (what kind?)
Sodium stibogluconate (Twave changes, QT prolongation)
