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Pharma > Other Antiprotozoal Drugs > Flashcards

Other Antiprotozoal Drugs Flashcards

0
Q

Blocks dihydropteroate synthase

A

Sulfamethoxazole

Sulfadiazine

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1
Q

Drugs for pneumocystosis and toxoplasmosis

A

Cotri
Pentamidine
Pyrethamine-Sulfadiazine

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2
Q

Blocks dihydrofolate reductase

A

Timethoprim

Pyrimethamine

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3
Q

DOC for prophylaxis and treatment of pneumocystosis

A

Cotri

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4
Q

Backup for prophulais and treatment of pneumocystosis

A

Pentamidine

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5
Q

DOC for prophylaxis and treatment of toxoplasmosis

A

Pyrimethamine-sulfadiazine

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6
Q

Prophylaxis for T. gondii and isospora belli

A

Cotri

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7
Q

Mode of administration of pentamidine

A

Aerosol/nasal spray

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8
Q

SE: hematotoxicity (what kind?)

A

Pyrimethamine-sulfadiazine (megaloblastic anemia, thrombocytopenia)

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9
Q

Displaces protein binding of other drugs

A

Cotri

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10
Q

Drugs for West African sleeping sickness

A

Early: Pentamidine
CNS: Eflornithine

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11
Q

Drugs for East African sleeping sickness

A

Early: Suramin
CNS: Melarsoprol

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12
Q

Drugs for trypanosomiasis that cross the BBB

A

Melarsoprol

Eflornithine

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13
Q

Drugs for trypanosomiasis that do not cross the BBB

A

Suramin

Pentamidine

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14
Q

Used for kala-azar

A

Pentamidine

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15
Q

Back up drug for onchocerciasis

A

Suramin

16
Q

Compare eflornithine and melarsoprol in terms of toxicity

A

Melarsoprol»eflornithine

17
Q

Suicide inhibitor of ornihine decarboxylase

A

Eflornithine

18
Q

Organic arsenical. Inhibits enzyme sulfhydryl groups in trypanosomes

A

Melarsoprol

19
Q

Inhibits trypanothione reductase

A

Nifurtimox

20
Q

DOC for leishmaniasis

A 
Sodium stinogluconate
(except in India - amphotericin B)
21
Q

Causes anemia, neutropenia, hepatitis, pancreatitis

A

Pentamidine

22
Q

Causes hemolytic anemia and agranulocytosis

A

Suramin

23
Q

Causes reactive encephalopathy

A

Melarsoprol

24
Q

Causes cardiotoxicity (what kind?)

A

Sodium stibogluconate (Twave changes, QT prolongation)

Pharma (11 decks)

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