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Pharma > Anifungals > Flashcards

Anifungals Flashcards

1
Q

SE of amphotericin B

A

Nephrotoxicity (RTA), Note: aminoglycosides-ATN

Infusion reaction

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2
Q

Flucytosine is accumulated in fungal cells by the action of _ and converted by _ to _ which inhibits _

A

Permease; cytosine deaminase; 5-FU; thimidylate synthase

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3
Q

Binds ergosterol in fungal membrane forming artificial pores

A

Amphotericin B

Nystatin

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5
Q

Use of flucytosine

A

Cryptococcosis
Systemic candida
Chromoblastomycosis

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6
Q

For salvage therapy for invasive aspergillosis

A

Caspofungin

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7
Q

Accumulated in fungal cells by the action of permease and converted by cytosine deaminase to 5-FU which inhibits thimidylate synthase

A

Flucytosine

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8
Q

Limited to topical use because of ustemic toxicity

A

Ketoconazole

Clotrimazole

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9
Q

Fungistatic

A

Flucytosine
Azoles
Capsofungin

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10
Q

Treatment for Madura foot

A

Flucytosine

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11
Q

Inhibit fungal CYP450 dependent enzymes blocking ergosterol synthesis

A

Azoles

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12
Q

Uses of ketoconazole

A

Chronic mucocutanrous candidiasis

Dermatophytosis

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13
Q

Potent CYP450 inhibitor

A

Ketoconazole

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15
Q

Interferes with microtubule function, inhibiting sythesis and polymerization of nucleic acids

A

Griseofulvin

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16
Q

For treatment and prophylaxis of cryptococcal meningitis

A

Fluconazole

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17
Q

Narrow antifungal spectrum

A

Ketoconazole

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18
Q

Available in swish and swallow preparation

A

Nytstatin

19
Q

Uses of fluconazole

A

Candidiasis
Coccidioidomycosis
Cryptococcal meningitis

20
Q

Inhibits B glucan sunhase decreasing bacterial cell wall synthesis

A

Caspofungin

21
Q

Use of griseofulvin

A

Dermatophytosis

22
Q

Griseofulvin is contraidicated in _

A

Porphyria

24
Q

Potent CYP450 inducer

A

Griseofulvin

25
Q

Minimal mucocutaneous absorption

A

Nystatin

26
Q

Use of terbinafine

A

Dermatophytosis

Onychomycosis

27
Q

Accumulates in keratin

A

Griseofulvin

Terbinafine

28
Q

Contraindicated in porphyria

A

Griseofulvin

29
Q

Use of clotrimazole

A

Mucocutaneos candidiasis
Dermatophytosis
Seborrheic dermatitis
Ptyriasis versicolor

30
Q

SE of nystatin

A

Nephrotoxicity

32
Q

Use of nystatin

A

Candidiasis

38
Q

Squalene oxidase inhibitor

A

Terbinafine

40
Q

Fungicidal

A

Amphotericin B
Nystatin
Terbinafine

45
Q

Pyrimidine antimetabolite

A

Flucytosine

Pharma (11 decks)

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