Anifungals

Question 1

SE of amphotericin B

Answer 1

Nephrotoxicity (RTA), Note: aminoglycosides-ATN

Infusion reaction

Question 2

Flucytosine is accumulated in fungal cells by the action of _ and converted by _ to _ which inhibits _

Answer 2

Permease; cytosine deaminase; 5-FU; thimidylate synthase

Question 3

Binds ergosterol in fungal membrane forming artificial pores

Answer 3

Amphotericin B

Nystatin

Question 5

Use of flucytosine

Answer 5

Cryptococcosis
Systemic candida
Chromoblastomycosis

Question 6

For salvage therapy for invasive aspergillosis

Answer 6

Caspofungin

Question 7

Accumulated in fungal cells by the action of permease and converted by cytosine deaminase to 5-FU which inhibits thimidylate synthase

Answer 7

Flucytosine

Question 8

Limited to topical use because of ustemic toxicity

Answer 8

Ketoconazole

Clotrimazole

Question 9

Fungistatic

Answer 9

Flucytosine
Azoles
Capsofungin

Question 10

Treatment for Madura foot

Answer 10

Flucytosine

Question 11

Inhibit fungal CYP450 dependent enzymes blocking ergosterol synthesis

Answer 11

Azoles

Question 12

Uses of ketoconazole

Answer 12

Chronic mucocutanrous candidiasis

Dermatophytosis

Question 13

Potent CYP450 inhibitor

Answer 13

Ketoconazole

Question 15

Interferes with microtubule function, inhibiting sythesis and polymerization of nucleic acids

Answer 15

Griseofulvin

Question 16

For treatment and prophylaxis of cryptococcal meningitis

Answer 16

Fluconazole

Question 17

Narrow antifungal spectrum

Answer 17

Ketoconazole

Question 18

Available in swish and swallow preparation

Answer 18

Nytstatin

Question 19

Uses of fluconazole

Answer 19

Candidiasis
Coccidioidomycosis
Cryptococcal meningitis

Question 20

Inhibits B glucan sunhase decreasing bacterial cell wall synthesis

Answer 20

Caspofungin

Question 21

Use of griseofulvin

Answer 21

Dermatophytosis

Question 22

Griseofulvin is contraidicated in _

Answer 22

Porphyria

Question 24

Potent CYP450 inducer

Answer 24

Griseofulvin

Question 25

Minimal mucocutaneous absorption

Answer 25

Nystatin

Question 26

Use of terbinafine

Answer 26

Dermatophytosis

Onychomycosis

Question 27

Accumulates in keratin

Answer 27

Griseofulvin

Terbinafine

Question 28

Contraindicated in porphyria

Answer 28

Griseofulvin

Question 29

Use of clotrimazole

Answer 29

Mucocutaneos candidiasis Dermatophytosis Seborrheic dermatitis Ptyriasis versicolor

Question 30

SE of nystatin

Answer 30

Nephrotoxicity

Question 32

Use of nystatin

Answer 32

Candidiasis

Question 38

Squalene oxidase inhibitor

Answer 38

Terbinafine

Question 40

Fungicidal

Answer 40

Amphotericin B Nystatin Terbinafine

Question 45

Pyrimidine antimetabolite

Answer 45

Flucytosine