Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharma > Antibiotics > Flashcards

Antibiotics Flashcards

0
Q

Renal tubular reabsorption of penicillin inhibited by _

A

Probenecid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Bacterial cell wall synthesis inhibitors

A

Penicillin
Cephalosporins
VACCIB (Vanc, aztreonam, cycloserine, clavulanic acid, imipinem, bacitracin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Renal tubular reabsorption inhibited by probenecid

A

Pen G

Pen V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inactivated by penicillamase

A

Pen G/V
Ampicillin/amoxicillin
Piperacillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Penicillin for staph infections

A

Methicillin
Nafcillin
Oxacillin
Cloxacillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Penicillin that can cause interstitial nephritis

A

Methicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Penicillin that can cause neutropenia

A

Nafcillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SE of methicillin

A

Interstitial nephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Narrow spectrum penicillin

A 
Pen G (inject)
Pen V (oral)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Coverage of amox/ampi

A 
HiB
E. coli
Listeria
Proteus
Salmonella
Enterococci
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Penicillin that can cause pseudomembranous colitis

A

Ampicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SE of ampicillin

A

Pseudomembranous colitis

Rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antipseudomonal penicillins

A

Ticarcillin
Piperacillin
Carbenicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Drug interaction of antipseudomonal penicillin with aminoglycosides

A

Synergism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Antipseudomonal penicillin that can cause bleeding

A

Ticarcillin (antiplatelet)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cephalosporin with greatest bone and tissue penetration

A

1st gen (cefazolin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Coverage of 1st gen cephalosporins

A

Gram positive

Proteus, E. coli, Klebsiella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Coverage of second gen cephalosporin

A

Gram positive

HiB, Enterobacter, Neisseria, Proteus, E. coli, Klebsiella, Serratia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Cephalosporins with disulfiram reaction

A

Cefamandole
Cefotetan
Cefoperazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Carbapenem

A

Imipinem
Meropenem
Ertapenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Inhibits renal metabolism of imipinem

A

Cilastatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Monobactam

A

Aztreonam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Coverage of aztreonam

A

Gram neg especially:

Klebsiella, Serratia, Pseudomonas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Uses of vancomycin

A 
Pseudomembranous colitis (oral)
MRSA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

SE of nafcillin

A

Neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Treatment of red man syndrome

A

Slow infusion of vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Drugs of last resort

A 
Imipinem
Amikacin
Meropenem
Linezolid
Streptogranin
Vancomycin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Beta lactamase inhibitors

A

Clavulanic acid
Sulbactam
Tazobactam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Glycopeptide that inhibits cell wall synthesis by binding to the D-ala-D-ala terminal of nascent peptidoglycan

A

Vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Peptide antibiotic that interferes with late stage in cell wall synthesis in gram positive organisms

A

Bacitracin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Reserved for topical use only due to nephrotoxicity

A

Bactracin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

SE of bacitracin

A

Nephrotixicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Ketolide

A

Telithromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Second line drug for drug-resistant TB (cell wall synthesis inhibitor)

A

Cycloserine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Antipseudomonal cephalosporins

A

Ceftazidime
Cefoperazone
Cefepime

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Bactericidal protein sythesis inhibitors

A

Aminoglycosides

Streptogramins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Bacteriostatic protein sythesis inhibitors

A 
Tetracycline
Chloramphenicol
Erythromycin (macrolides)
Lincosamides (clindamycin)
Linezolid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

SE of vanco

A

Red man syndrome

Nephrotoxic, ototoxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Inhibits translocation

A

Lincosamides (clinda)

Macrolides (erythro)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Inhibits initiation complex in protein synthesis

A

Streptomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Inhibits binding of tRNA to A site

A

Tetracycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Inhibits transpeptidation

A

Chloramphenicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Back up for salmonella, rickettsia, bacteroides

A

Chloramphenicol

43
Q

Inhibits DNA-dependent RNA polymerase

A

Rifampin

44
Q

Decreased RBC, cyanosis and CVS collapse

A

Gray baby syndrome

45
Q

SE of chloramphenicol

A 
Grey baby syndrome
Aplasic anemia (ideosyncratic)
46
Q

Protein synthesis inhibitor that can benused for SIADH

A

Demeclocycline

47
Q

Enzyme problem in gray baby syndrome

A

Glucoronosyltransferase

48
Q

Broadest spectrum tetracycline

A

Tigecycline

49
Q

Teratogenic effect of tetracycline

A

Tooth enamel dysplasia/discoloration

50
Q

Do not take tetracycline with _ because _

A

Milk decreases absorption

51
Q

Aminoglycoside with reverse neuromuscular blockade with calcium gluconate and neostigmine

A

Neomycin
Kanamycin
Paromomycin

52
Q

Macrolide with highest Vd and slowest elimination

A

Azithromycin

53
Q

Used for macrolide-resistance

A

Telithromycin

54
Q

All macrolides inhibit CYP450 except _

A

Azithromycin

55
Q

Protein synthesis inhibtor that is a backup drug against gram positive cocci

A

Clindamycin

56
Q

Cross ressistance between clinda and _ is common

A

Macrolides

57
Q

Treatment for anaerobic infections above and below diaphragm

A

Above: clindamycin
Below: metronidazole

58
Q

Streptogramin

A

Quinupristin

Dalfopristin

59
Q

Protein synthesis inhibitor for drug-resistant gram positive cocci

A

Quinupristin
Dalfopristin
Linezolid (listeria, corynebacteria)

60
Q

Protein synthesis inhibitor that can cause serotonin syndrome

A

Linezolid

61
Q

Killing action continues when their plasma levels have declined below measureable levels. Seen in?

A

Postantibiotic effect

Aminoglyosides and fluoroquinolonea

62
Q

Aminoglycoside with narrowest therapeutic window

A

Amikacin

63
Q

Mode of excretion of aminoglycosides

A

Glomerular filtration

64
Q

Require oxygen

A

Aminoglycosides

65
Q

Protein synthesis inhibitor that causes pseudomembranous colitis

A

Clindamycin

66
Q

Side effects of animoglycosides

A

Nephrotoxicity (reversible)
Ototoxicity (irreversible)
Teratogenic

67
Q

Aminoglycosides are synergistic with _

A

Beta lactams

68
Q

Most nephrotoxic aminoglycosides

A

Gentamicin

Tobramycin

69
Q

Aminoglycoside that is a second line drug for MDRTB

A

Amikacin

70
Q

Coverage of streptomycin

A

TB
Tularemia
Bubonic plague
Brucellosis

71
Q

Aminoglycoside administered IM

A

Streptomycin

72
Q

Teratogenic effect of aminoglycosides

A

Deafness

73
Q

Aminoglycoside for visceral leishmaniasis

A

Paromomycin

74
Q

Most common drug trigger for SJS/TEN, EM, PAN, exfoliative dermatitis

A

Sulfonamides

75
Q

Most common drug trigger for SJS/TEN, EM, PAN, exfoliative dermatitis

A

Sulfonamides

76
Q

Most ototoxic aminoglycoside

A

Kanamycin

Amikacin

77
Q

Aminoglycosides limited to topical and oral use

A

Neomycin
Kanamycin
Paromomycin

78
Q

Aminoglycoside for hepatic encephalopathy

A

Neomycin

79
Q

Most vestibulotoxic aminoglycosides

A

Tobramycin

Gentamicin

80
Q

Aminoglycoside for drug-resistant gonorrhea

A

Spectinomycin

81
Q

Cummulative ototoxicity of aminoglycosides when used with _

A

Loop diuretics

82
Q

Nephrotoxicity of aminoglycosides

A

ATN

83
Q

Short acting antifolate drug

A

Sulfisoxazole

84
Q

Intermediate-acting anti-folate drug

A

Sulfamethoxazole

85
Q

Long acting antifolate drug

A

Sulfadoxine

86
Q

Enzyme blocked by sulfonamides

A

Dihydropteroate synthase (competitive inhibition)

87
Q

Enzyme blocked by trimethoprim

A

Dihydrofolate reductase

88
Q

Sulfonamide with poor eschar penetration

A

Silver sulfadiazine

89
Q

Sulfonamide with good eschar penetration

A

Mafenide acetate

90
Q

Antibiotic for burn infection

A

Silver sulfadiazine

Mafenide acetate

91
Q

Backup med for cholera

A

Cotrimoxazole

92
Q

Crossover biochem:

Topoisomerase I and II

A

1: swivelase
2: gyrase

93
Q

Enzyme inhibited by fluoroquinolones

A

Topoisomerase 2 (DNA gyrase) and 4

94
Q

Second gen fluoroquinolones

A

Ciprofloxacin
Ofloxacin
Norfloxacin

95
Q

SE of FQ

A

Tendinitis

Tendon rupture

96
Q

Third gen FQ

A

Levofloxacin

97
Q

FQ enhance toxicity of _

A

Methylxanthines (theophylline)

98
Q

FQ withdrawn due to severe cardiotoxicity (arrhythmia)

A

Grepafloxacin (3rd gen)

99
Q

4th gen FQ

A

Moxifloxacin

100
Q

FQ with SE: diabetes

A

Gatifloxacin (4th gen)

101
Q

FQ with SE: hepatotoxicity

A

Trovafloxacin

102
Q

Antibiotics for pseudonembranous colitis

A

Metronidazole

Vancomycin

103
Q

Antibiotic with SE: metallic taste

A

Metronidazole

104
Q

Nitrofurantoin use

A

UTI except proteus and pseudomonas

105
Q

Spectrum of sulfonamide hypersensitivity

A

EM
SJS/TEN
PAN
Exfoliative dermatitis

106
Q

First generation FQ

A

Nalixidic acid

Pharma (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions