Antimycobacterials

Question 0

Butanol derivative

Answer 0

E

Question 1

Nicotinic acid derivative

Answer 1

H

Question 2

Inhibits mycolic acid synthesis

Answer 2

H

Question 3

Inhibits DNA dependent DNA polymerase

Answer 3

R

Question 4

Inhibits arabynosyl transferases involved in synthesis of arabinoglycan in mycobacterial cell wall

Answer 4

E

Question 5

Unknown MOA

Answer 5

Z

Question 6

Inhibit protein synthesis by binding to 30s subunit

Answer 6

S

Question 7

Most important virulence factor of TB

Answer 7

Cord factor/trehalose mycolate

Question 8

Bactericidal

Answer 8

HRS
Z (may be static)

Question 9

SE of isoniazid

Answer 9

Hepatitis
Neurotoxicity
Hemolysis in G6PD
Drug-induced lupus

Question 11

SE: red orange urine

Answer 11

R

Question 12

SE: hepatotixicity

Answer 12

H<Z

Question 13

SE: color blindness (what kind?)

Answer 13

E (red green)

Question 14

SE of Z

Answer 14

Hepatotoxicity

Hyperuricemia

Question 16

For TB prophylaxis

Answer 16

H

Question 17

Prophylaxis for meningococcal and staphylococcal carrier states

Answer 17

R

Question 18

Coverage of streptomycin

Answer 18

TB
Tularemia
Bunonic plague
Brucellosis

Question 19

Most important drug in TB

Answer 19

H

Question 20

Potent CYP450 inducer

Answer 20

R

Question 21

Most hepatitixic anti-TB drug

Answer 21

Z

Question 24

Potent CYP450 inhibitor

Answer 24

H

Question 25

Prevent neurotixicity of H by co-administering _

Answer 25

Pyridoxine

Question 26

Administered IM

Answer 26

S

Question 27

Aka sterilizing agent

Answer 27

Z

Question 28

For S-resistant or MDR strains

Answer 28

Amikacin

Question 29

Active against strains of M. tb resistant to first line agents

Answer 29

Cipro, oflox

Question 30

Sulfone

Answer 30

Dapsone

Question 31

Phenazine dye

Answer 31

Clofazimine

Question 32

Inhibits folic acid synthesis

Answer 32

Dapsone

Question 33

Ninds to guanine bases in bacterial DNA

Answer 33

Clofazamine

Question 34

Most active drug against M. leprae

Answer 34

Dapsone

Question 35

SE of dapsone

Answer 35

Methemoglobinemia | Hemolysis in G6PD

Question 36

Dapsone is usually used in combination with _

Answer 36

Rifampicin and clofazimine

Question 37

Prophylaxis for atypical mycobacteria

Answer 37

Clarithro/azithro +/- rifabutin if CD4<50

Question 38

Treatment for atyoical mycobacteria

Answer 38

Azithro/clarithro + ethambutol + rifabutin

Question 39

Bacteriostatic but can be bactericidal

Answer 39

Z

Question 41

Rapid development of resistance if used alone

Answer 41

R

Question 42

Bacteriostatic

Answer 42

E | Z (may be cidal)

Question 44

SE of S

Answer 44

Nephrotoxicity (reversible) Ototoxicity (irreversible) Teratogenic (congenital deafness)