Antimalarials

Question 0

Gametocide

Answer 0

Primaquine

Question 1

Tissue schizonticides

Answer 1

Primaquine

Atravaquone

Question 2

Sporonticides

Answer 2

Proguanil

Pyrimethamine

Question 3

Prevents polymerization of heme into hemozoin

Answer 3

Chloroquine

Question 4

Complexes with DBA to prevent strand separation

Answer 4

Quinine

Question 5

Unknown MOA

Answer 5

Mefloquine

Halofantrine

Question 6

Forms electron transferring redox compounds that act as cellular oxidants

Answer 6

Primaquine

Question 7

Disrupts mitochondrial ETC

Answer 7

Atovaquone

Question 8

Inhibits folate synthesis

Answer 8

Proguanil

Question 9

Sequential blocking of folic acid synthesis

Answer 9

Sulfadoxine-Pyrimethamine

Question 10

Impairs progeny of malarial apicoplast genes resulting in abbormal cell division

Answer 10

Doxycycline

Question 11

Forma toxic free radicals in malarial food vacuoles

Answer 11

Artemsinin

Question 12

Antimalarial and DMARD

Answer 12

Chloroquine

Question 13

Chloroquine may precipitate _

Answer 13

Porphyria

Question 14

SE of quinine

Answer 14

Cinchonism

Question 15

Triad of cinchonism

Answer 15

Headache
Tinnitus
Vertigo

Question 16

Alternative to quinine in acute attacks of falciparum malaria

Answer 16

Mefloquine

Question 17

Causes hemolysis in G6PD deficiency

Answer 17

Quinine

Primaquine

Question 18

Decreased absorption with milk

Answer 18

Doxycycline

Tetracycline

Question 19

Co-Atrem

Answer 19

Artemsinin + lumefantrine

Question 20

Chemoprophylaxis for chloroquine-sensitive areas

Answer 20

Chloroquine

Question 21

Chemoprophylaxis for chloroquine-resistant areas

Answer 21

Mefloquine

Atavaquone-proguanil

Question 22

SE of primaquine

Answer 22

Methemoglobinemia

Hemolysis in G6PD deficiency

Question 23

Competition for plasma protein binding sites with other drugs

Answer 23

Sulfadoxine-pyrimethamine

Question 24

Chemoprophylaxis for multi-drug resistant malaria

Answer 24

Doxycycline

Question 25

Treatment for uncomplicated falciparum

Answer 25

Artemsinin

Question 26

May precipitate porphyria

Answer 26

Chloroquine

Question 27

Can cause blackwater fever

Answer 27

Quinine

Question 28

Should be used with a blood schizonticide

Answer 28

Primaquine

Question 29

DOC for uncomplicated falciparum malaria in the Phil

Answer 29

Co-Artem

Question 30

SE: cardiotoxicity. What kind?

Answer 30

Halofantrine | Prolongs PR and QT interval

Question 31

SE: Myocardial depression, retinal damage, auditory impairment

Answer 31

Chloroquine

Question 32

Quinine is commonly used with _ and _ to _

Answer 32

Doxycycline or clindamycin to limit toxicity

Question 33

SE: folic acid deficiency

Answer 33

Pyrimethamine

Question 34

SE: hepatotoxicity, nephrotoxicity, photosensitivity, vestibulotoxicity

Answer 34

Doxycycline

Question 35

Teratogenic

Answer 35

Doxycycline (tooth enamel dysplasia/discoloration) | Halofantrine

Question 36

Fatal complication of quinine-sensitized persons

Answer 36

Blackwater fever

Question 37

Blocks DNA replication and transcription

Answer 37

Quinine