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Antivirals Flashcards

0
Q

Inhibits viral RNA polymerase, DNA polymerase and HIV reverse transcriptase

A

Foscarnet

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1
Q

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

A

Acyclovir

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3
Q

Acyclovir has no activity against strains of HSV with absent _

A

Thymidine kinase activity

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4
Q

For HSV infection in patients with AIDS

A

Foscarnet

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5
Q

Anti-HSV that inhibits fusuon between HSV envelope and plasma membranes

A

Docosanol

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7
Q

Uses of acyclovir

A

HSV 1 and 2

VZV

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8
Q

Binds to pyrophosphate binding site

A

Foscarnet

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9
Q

Causes nephrotoxicity (cystalluria)

A

Acyclovir

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10
Q

Inhibits viral DNA polymerase. Do not need thymidine kinase.

A

Ganciclovir

Cifodovir

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12
Q

Uses of ganciclovir

A

HSV 1 and 2
VZV
CMV

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13
Q

SE of cifoduvir

A

Nephrotoxicity

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14
Q

Causes leukopenia, trombocytopenia and neutropenia

A

Ganciclovir

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15
Q

For CMV retinitis

A

Cifodovir

Foscarnet

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16
Q

Causes electrolyte abnormality

A

Foscarnet (hypocalcemia)

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17
Q

Inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes

A

Zidovudine (NRTI)

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18
Q

Inhibit HIV reverse transcriptase without requiing phosphorylation

A

Delavirdine (NNRTI)

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19
Q

For prevention of maternal-fetal HIV transmission

A

Zidovudine (NRTI)
Give to mother prior and during delivery
Give to baby after delivery

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20
Q

Causes lactic acidosis with hepatic steotosis

A

NRTI

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21
Q

NRTI that causes bone marrow suppression

A

Zidovudine

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22
Q

NRTI that causes hypersensitivity

A

Abacavir

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23
Q

NRTI that causes pancreatitis

A

Didanosine

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24
Q

NRTI that causes peripheral neuropathy

A

Stavudine

Zalcitabine

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25
Q

NNRTI that causes rash, inc AST/ALT

A

Delavirdine

Nevirapine

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26
Q

NNRTI with teratogenicity

A

Efavirenz

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27
NNRTI with inc cholesterol and triglycerides
Etravirine
28
Noncompetitive inhibitors of reverse teanscriptase
NNRTI
29
Reverse transcriptase inhibitors that do not incorporate in chain
NNRTI
30
Inhibit movement of reverse transcriptase
NNRTI
31
Analogue of deoxynucleotides. Incorporate in growing DNA chain
NRTI
32
Protease inhibitor
Indinavir
33
Fusion inhibitor
Enfuvirtide
34
CCR5 receptor antagonist
Maraviroc
35
For influenza A
Amantadine
37
Inhibit viral processing
Indinavir
38
Enfuvirtide binds to _ subunit of viral envelop preventing fusion of viral and cellular membranes
Gp41
39
Causes fat redistribution, hyperglycemia, hyperlipidemia, insulin resistance
Protease inhibitors
40
Binds to gp41 subunit of viral envelop preventing fusion of viral and cellular membranes
Enfuvirtide
41
Prevents viral uncoating
Amantadine
43
Blocks viral attachment via transmembrane chemokine receptor CCR5
Maraviroc
44
No cross-resistance with other anti-HIV drugs
Enfuvirtide
45
Minimal cross-resistance with other anti-HIV drugs
Maraviroc
46
SE of indinavir
Hyperbilirubinemia and nephrolithiasis
47
SE of amprenavir
Rash
48
Causes cerebellar dysfunction
Amantadine
49
Inhibits guanosine triphosphate formation
Ribavirin
50
SE of atazanavir
Peripheral neuropathy
51
For influenza A and B
Oseltamivir
52
SE of saquinavir
GI distress and diarrhea
53
SE of oseltamivir
GI effects
55
SE of zanamivir
Bronchospasm in asthmatics
56
Presently the DOC for influenza
Oseltamivir
57
Uses of amantadine
Influenza A | Rubella
58
Blocks RNA-dependent RNA polymerases
Ribavirin
59
Causes livedo reticularis
Amantadine
60
Inhibits neuraminidase
Oseltamivir
61
Amantadine prevents uncoating by binding to _
M2 proton channels
64
Prevents capping of mRNA
Ribavirin
65
For hep B
Interferon a | Lamivudine
67
Use of lamivudine for HBV HCV coinfection can increase risk for _
Pancreatitis
69
Degrades viral RNA via activation of host cell RNAse
Interferon a
70
Use of interferon a
HBV HCV Kaposi sarcoma Genital warts
71
Contraindications of interferon a
Autoimmune disease Cardiac arrhythmia Pregnancy
72
Uses of lamivudine
HBV | HIV
73
SE of adefovir
Lactic acidosis | Renal and hepatic toxicity
74
Use of ribavirin
HCV | RSV
75
Early administration decreases mortality in viral helorrhagic fevers
Ribavirin
76
SE of entecavir
Headache Dizziness Fatigue Nausea

Pharma (11 decks)

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