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Pharma > Antivirals > Flashcards

Antivirals Flashcards

0
Q

Inhibits viral RNA polymerase, DNA polymerase and HIV reverse transcriptase

A

Foscarnet

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1
Q

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

A

Acyclovir

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3
Q

Acyclovir has no activity against strains of HSV with absent _

A

Thymidine kinase activity

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4
Q

For HSV infection in patients with AIDS

A

Foscarnet

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5
Q

Anti-HSV that inhibits fusuon between HSV envelope and plasma membranes

A

Docosanol

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7
Q

Uses of acyclovir

A

HSV 1 and 2

VZV

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8
Q

Binds to pyrophosphate binding site

A

Foscarnet

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9
Q

Causes nephrotoxicity (cystalluria)

A

Acyclovir

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10
Q

Inhibits viral DNA polymerase. Do not need thymidine kinase.

A

Ganciclovir

Cifodovir

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12
Q

Uses of ganciclovir

A

HSV 1 and 2
VZV
CMV

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13
Q

SE of cifoduvir

A

Nephrotoxicity

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14
Q

Causes leukopenia, trombocytopenia and neutropenia

A

Ganciclovir

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15
Q

For CMV retinitis

A

Cifodovir

Foscarnet

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16
Q

Causes electrolyte abnormality

A

Foscarnet (hypocalcemia)

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17
Q

Inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes

A

Zidovudine (NRTI)

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18
Q

Inhibit HIV reverse transcriptase without requiing phosphorylation

A

Delavirdine (NNRTI)

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19
Q

For prevention of maternal-fetal HIV transmission

A

Zidovudine (NRTI)
Give to mother prior and during delivery
Give to baby after delivery

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20
Q

Causes lactic acidosis with hepatic steotosis

A

NRTI

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21
Q

NRTI that causes bone marrow suppression

A

Zidovudine

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22
Q

NRTI that causes hypersensitivity

A

Abacavir

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23
Q

NRTI that causes pancreatitis

A

Didanosine

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24
Q

NRTI that causes peripheral neuropathy

A

Stavudine

Zalcitabine

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25
Q

NNRTI that causes rash, inc AST/ALT

A

Delavirdine

Nevirapine

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26
Q

NNRTI with teratogenicity

A

Efavirenz

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27
Q

NNRTI with inc cholesterol and triglycerides

A

Etravirine

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28
Q

Noncompetitive inhibitors of reverse teanscriptase

A

NNRTI

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29
Q

Reverse transcriptase inhibitors that do not incorporate in chain

A

NNRTI

30
Q

Inhibit movement of reverse transcriptase

A

NNRTI

31
Q

Analogue of deoxynucleotides. Incorporate in growing DNA chain

A

NRTI

32
Q

Protease inhibitor

A

Indinavir

33
Q

Fusion inhibitor

A

Enfuvirtide

34
Q

CCR5 receptor antagonist

A

Maraviroc

35
Q

For influenza A

A

Amantadine

37
Q

Inhibit viral processing

A

Indinavir

38
Q

Enfuvirtide binds to _ subunit of viral envelop preventing fusion of viral and cellular membranes

A

Gp41

39
Q

Causes fat redistribution, hyperglycemia, hyperlipidemia, insulin resistance

A

Protease inhibitors

40
Q

Binds to gp41 subunit of viral envelop preventing fusion of viral and cellular membranes

A

Enfuvirtide

41
Q

Prevents viral uncoating

A

Amantadine

43
Q

Blocks viral attachment via transmembrane chemokine receptor CCR5

A

Maraviroc

44
Q

No cross-resistance with other anti-HIV drugs

A

Enfuvirtide

45
Q

Minimal cross-resistance with other anti-HIV drugs

A

Maraviroc

46
Q

SE of indinavir

A

Hyperbilirubinemia and nephrolithiasis

47
Q

SE of amprenavir

A

Rash

48
Q

Causes cerebellar dysfunction

A

Amantadine

49
Q

Inhibits guanosine triphosphate formation

A

Ribavirin

50
Q

SE of atazanavir

A

Peripheral neuropathy

51
Q

For influenza A and B

A

Oseltamivir

52
Q

SE of saquinavir

A

GI distress and diarrhea

53
Q

SE of oseltamivir

A

GI effects

55
Q

SE of zanamivir

A

Bronchospasm in asthmatics

56
Q

Presently the DOC for influenza

A

Oseltamivir

57
Q

Uses of amantadine

A

Influenza A

Rubella

58
Q

Blocks RNA-dependent RNA polymerases

A

Ribavirin

59
Q

Causes livedo reticularis

A

Amantadine

60
Q

Inhibits neuraminidase

A

Oseltamivir

61
Q

Amantadine prevents uncoating by binding to _

A

M2 proton channels

64
Q

Prevents capping of mRNA

A

Ribavirin

65
Q

For hep B

A

Interferon a

Lamivudine

67
Q

Use of lamivudine for HBV HCV coinfection can increase risk for _

A

Pancreatitis

69
Q

Degrades viral RNA via activation of host cell RNAse

A

Interferon a

70
Q

Use of interferon a

A

HBV
HCV
Kaposi sarcoma
Genital warts

71
Q

Contraindications of interferon a

A

Autoimmune disease
Cardiac arrhythmia
Pregnancy

72
Q

Uses of lamivudine

A

HBV

HIV

73
Q

SE of adefovir

A

Lactic acidosis

Renal and hepatic toxicity

74
Q

Use of ribavirin

A

HCV

RSV

75
Q

Early administration decreases mortality in viral helorrhagic fevers

A

Ribavirin

76
Q

SE of entecavir

A

Headache
Dizziness
Fatigue
Nausea

Pharma (11 decks)

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