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Pharma > DMARDs > Flashcards

DMARDs Flashcards

0
Q

Forms phosphoramide mustard which crosslinks DNA to prevent cell replication

A

Cyclophosphamide

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1
Q

Inhibits AICAR transformylase and thymidylate synthetase with secondary effects on PMN chemotaxis

A

Methotrexate

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2
Q

Binds to TNF-a and prevents it from activating TNF-a receptors

A

Infliximab

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3
Q

Suppression of T lymphocyte responses to mitogens

A

Chloroquine

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4
Q

Suppresses inosinic acid synthesis, B and T cell function, Ig production and IL2 secretion

A

Azathioprine

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5
Q

Decreases leukocyte chemotaxis

A

Chloroquine

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6
Q

Active metabolite inhibits releasenof inflammatory cytokines

A

Sulfasalazine

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7
Q

Stabilization of lysosomal enzymes, trapping of free radicals

A

Chloroquine

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8
Q

Inhibits IL1 and IL2 receptor production

A

Cyclosporin

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9
Q

Active metabolite inhibits inosine monophosphate drhydrogenase and Tcell lymphocyte proliferation

A

Mycophenolate mofetil

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10
Q

Active metabolite of sulfasalazine

A

Sulfapyridine

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11
Q

First choice to treat RA

A

Methotrexate

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12
Q

Rescue agent of cyclophosphamide

A

Mesna

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13
Q

Synergistic effect with methotrexate

A

Infliximab

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14
Q

Rescue agent for methotrexate

A

Leucovorin/folinic acid

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15
Q

Cannot give with azathioprine. Why?

A

Allopurinol

Can lead to leukopenia

16
Q

Purine antimetabolite

A

Azathioprine

17
Q

Safe for pregnant women

A

Chloroquine

18
Q

SE: hemorrhagic cystitis

A

Cyclophosphamide secondary o acrolein

19
Q

Causes psudolymphomatous reaction

A

Methotrexate

20
Q

Causes reactivation of TB and HepB

A

Infliximab

21
Q

SE: ocular toxicity

A

Chloroquine

22
Q

Causes gingival hyperplasia

A

Cyclosporin

23
Q

Causes reversible myelosuppression (neutropenia)

A

Mycophenolate mofetil

24
Q

Causes reversible infertility in men

A

Sulfasalazine

25
Q

Causes methemoglobinemia

A

Sulfasalazine

26
Q

Treatment for Crohn’s

A

Infliximab

27
Q

Treatment for Behcet’s

A

Azathioprine

28
Q

Treatment for ankylosing spondylitis

A

Sulfasalazine

Pharma (11 decks)

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