Osteoporosis Therapy: Sclerostin Inhibitor Flashcards
1
Q
Sclerostin inhibitor
A
Romosozumab
2
Q
Romosozumab brand name
A
Evenity
3
Q
Romosozumab MoA
A
Increases bone formation and decreases bone resorption
4
Q
Romosozumab dosing
A
210mcg SQ QD (2, 105mcg injections given consecutively by a HCP)
5
Q
Romosozumab ADEs
A
Nasopharyngitis, arthralgia, injection site reactions, hypocalcemia
Rare but severe: ONJ, atypical femur fracture
6
Q
Romosozumab BBW
A
MI, stroke, CV death
7
Q
Romosozumab clinical pearl
A
Therapy is limited to 12 months because the anabolic effect wanes after that amount of time, so follow-up with an antiresorptive agent
8
Q
Romosozumab is…
A
…BOTH an ANTIRESORPTIVE and ANABOLIC agent
