Osteoporosis Therapy: Parathyroid Hormone Analogs

Question 1

Parathyroid hormone analog drugs

Answer 1

Teriparatide, abaloparatide

Question 2

Teriparatide brand name

Answer 2

Forteo

Question 3

Abaloparatide brand name

Answer 3

Tymlos

Question 4

Parathyroid hormone analog MoA

Answer 4

Preferential stimulation of osteoBLASTIC activity over osteoclastic activity

Question 5

Teriparatide dosing

Answer 5

20mcg SQ QD

Question 6

Abaloparatide dosing

Answer 6

80mcg SQ QD

Question 7

Teriparatide ADEs

Answer 7

Leg cramps, dizziness/orthostatic hypotension, pain/arthralgia, nausea, cough, injection site reaction, hypercalcemia

Question 8

Abaloparatide ADEs

Answer 8

Dizziness/orthostatic hypotension, palpitations, nausea, hyperuricemia, hypercalciuria, injection site reaction, hypercalcemia

Question 9

Parathyroid hormone analog BBW

Answer 9

Osteosarcoma

Question 10

Parathyroid hormone analog pearl

Answer 10

Once therapy is stopped, bone loss can be rapid so alternative agents should be considering upon D/C’ing

Question 11

Parathyroid hormone analogs are…

Answer 11

ANABOLIC agents