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PHM 602- Thyroid, Osteoporosis, Women's Health > Infertility Drugs (MoA and Clinical Pearls) > Flashcards

Infertility Drugs (MoA and Clinical Pearls) Flashcards

1
Q

Clomiphene citrate MoA

A

Inhibits negative feedback loop in HPO axis by blocking estrogen receptor in the hypothalamus

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2
Q

Clomiphene citrate pregnancy rate

A

30%

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3
Q

Clomiphene citrate multiple gestations rate

A

7.98%

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4
Q

Clomiphene citrate can be used for how many cycles?

A

6 cycles

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5
Q

Letrozole MoA

A

Inhibits aromatase to decrease androgen and produce a hypoestrogenic state

May also thin cervical mucus

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6
Q

Letrozole pregnancy rate

A

23%

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7
Q

Letrozole multiple gestations rate

A

13%

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8
Q

Letrozole can be used for how many cycles?

A

5 cycles

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9
Q

Letrozole is a ?-line agent for infertility.

A

First

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10
Q

Follitropin alpha/follitropin beta MoA

A

Stimulates ovarian follicular growth

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11
Q

Follitropin alpha/beta pregnancy rate

A

35%

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12
Q

Follitropin alpha/beta multiple gestations rate

A

32%

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13
Q

Follitropin alpha/beta clinical pearls

A

Can also be given to men to stimulate spermatogenesis

Patients take this if they fail PO agents or they have certain disease states

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14
Q

Leuprolide MoA

A

Stimulates GnRH to the point where GnRH production is antagonized

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15
Q

Leuprolide therapy shouldn’t exceed more than…

A

12 months

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16
Q

Leuprolide is always given with

A

Gonadotropins

17
Q

Cetorelix, ganirelix MoA

A

Inhibit GnRH production to allow time for gonadotropin to work

18
Q

Cetorelix, ganirelix clinical pearls

A

Higher risk of OHSS and multiple births

19
Q

hCG: Novarel, Pregnyl
r-hCG: Ovidrel

MoA for both

A

Stimulates ovulation

20
Q

Clomiphene citrate drug class

A

SERM

21
Q

Letrozole drug class

A

Aromatase inhibitor

22
Q

Follitropin alpha/beta drug class

A

Gonadotropin (FSH)

23
Q

Leuprolide drug class

A

Gonadotropin-releasing hormone AGONISTS

24
Q

Cetrorelix, Ganirelix drug class

A

Gonadotropin-releasing hormone ANTAGONISTS

PHM 602- Thyroid, Osteoporosis, Women's Health (23 decks)

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