Ornithosis Chlamydophila psittaci

Question 1

type

Answer 1

Family:
chlamydiaceae
Genus:
chlamydophila
Obligate
intracellular,
G-ve
Parasite of
eukaryotic cells

Question 2

transmission

Answer 2

Inhalation of
excreta, urine
or respiratory
droplets from
WILD BIRDS

Question 3

risk factors

Answer 3

No person to
person (rare)
Natural
reservoir: Birds
High risk:Vets,zookeepers,Pet shop
owners,poultry

Question 4

pathogenesis

Answer 4

1. First spread to RES
   of liver, kidney and
   produce necrosis →
   seed to lung via
   blood causing
   lymphocytic
   inflammation in
   alveoli → edema,
   thickening of
   alveolar wall,
   infiltration of
   macrophages,
   necrosis &
   occasional
   hemorrhages.

Question 5

symptoms presentation

Answer 5

Sx: headaches, high fever(not
seen in Atypical pneumonia),
chills, myalgia
Pulm sx: nonproductive
cough, consolidation
CNS sx common: encephalitis,
convulsions, coma & death
GI sx: nausea, vomiting,
diarrhea
Other sx: Hepatomegaly,
splenomegaly, follicular
keratoconjunctivitis

Question 6

biphasic lifestyle

Answer 6

Metabolically inactive:
Infectious Elementary
bodies(EBs). Intact EB outer
membrane inhibits fusion to
the lysosome so no killing of
Chlamydia
- Metabolically active, non
infectious forms: Reticulate
bodies(RBs)
- causes Lysis of cells and
inclusions (in pneumoniae sp
reverse endocytosis)
18-24 hrs RBs divide to become
smaller EBs again, rupturing the
host cell

Question 7

features

Answer 7

1. No peptidoglycan in
   cell wall LPS with weak
   endotoxicity
2. Major Outer
   Membrane
   protein(MOMP) major
   cell wall component
   and unique to each
   species - antigen
   variation and what host
   it will infect

Question 8

treatment and prognosis

Answer 8

No vaccines
Tx infected
birds with
antibiotics
Pt isolation &
antibiotic tx