Coxiella Burnetii Q fever

Question 1

type

Answer 1

Family:
coxiellaceae
Obligate intracellular
G-ve bacteria

Question 2

transmission

Answer 2

Inhalation of
aerosols

Question 3

Zoonosis
Reservoir

Answer 3

cattle, sheep,
goats(ticks for
lifecycle)–>exc
reted out

Question 4

presentation

Answer 4

1. Self limiting flu like illness
2. Pneumonia(in N
   America)
3. Hepatitis(in europe)

Question 5

risk factors

Answer 5

1. Pre Existing heart
   defects
2. Pregnancy
3. Immunocompromised

Question 6

pathogenesis

Answer 6

LPS helps in long survival time

Question 7

phase 1

Answer 7

highly infectious
with intact smooth LPS -
intracellular

Question 8

phase 2

Answer 8

within in vitro- not
infectious Rough
LPS(truncated LPS)

Question 9

diagnostic

Answer 9

Serology depends on Phase
Phase 1; acute
Phase 2: chronic
IgM peaks at 4-6
weeks