Coronavirus Flashcards
1
Q
Category
A
Includes RSV, EBV, HPIV
Family: coronaviridae
2
Q
Properties
A
Largest Linear +ssRNA helical enveloped
4 genera: alpha, beta, gamma, delta
3
Q
Virulence Factors
A
- E2(peplomeric glycoprotein- Spike
protein) - Envelope spikes - binding
to host cell; fusion activity entry of
virus into host cell - H1 hemagglutination protein:
binding, entry - L(polymerase): infected cell- RNA
polymerase activity - N nucleoprotein
- E1 : transmembrane
4
Q
Season
A
Winter
5
Q
Incubation Period
A
2-5 days
6
Q
Survival time
A
3 hrs
7
Q
Epidemiology & risk
factors
A
Transmission: airborne droplets
Second most common cause of common
cold
8
Q
Vaccination
A
no
9
Q
Pathogenesis
A
Replication occurs in cytoplasm
- Virus assembled & obtains its
envelope from ER not from plasma
membrane
10
Q
Pathogenicity
A
Optimal Temp: 33-34C in ciliated nasal
epithelium - URTI
11
Q
Scenario
A
Common cold and virus causes
hemagglutination
