Chlamydophila pneumoniae(T WAR- Taiwan Acute respiratory Agent)

Question 1

type

Answer 1

a
pneumoniae(T
WAR- Taiwan
Acute
respiratory
Agent)
Obligate
intracellular
Gram -ve

Question 2

transmission and risk factors

Answer 2

Common in
“middle age”
children 5-15
yrs
No special risk
groups

Question 3

features

Answer 3

Biphasic life cycle
● Elementary
bodies(EB)-
infectious form
● Reticulate
bodies(RB):
intracellular
form-metabolically active

Question 4

presentation

Answer 4

Atypical pneumonia

Question 5

pathogenesis

Answer 5

EB attach to cell surface →
endocytosis → EB in endosome
which does not fuse with
lysosome → EB reorganizes
into reticulate bodies (RB) in
endosome → RB replicates by
binary fission → reorganized to
EBs → Inclusion granule has
both RBs and EBs→ reverse

Question 6

diagnostic

Answer 6

Hard to stain
Serology, PCR