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Pharm Block 3 > Opioids > Flashcards

Opioids Flashcards

1
Q

Morphine

A

Mu receptor
1st pass effect
4-5 hours

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2
Q

Fentanyl

A

Mu receptor
100x potency of Morphine
Short acting 1 hour
injection or patch

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3
Q

Methadone

A

Mu receptor
used for chronic pain
long duration of action

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4
Q

Meperidine

A

Mu Receptor
short duration
toxic metabolite
interact with MAO inhibitors

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5
Q

Heroin

A

Mu receptor
activated via metabolism
more lipophilic

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6
Q

Codeine

A

Mu receptor
activated via metabolism
Cough suppressant
used with NSAIDS

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7
Q

Oxycodone

A

Mu receptor

used with NSAIDS

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8
Q

Hyrdrocodone

A

Mu Receptor
Cough Suppressant
used with NSAID

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9
Q

Hydromorphone

A

Mu Receptor

2-3x morphine

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10
Q

B-Endorphin

A

Endogenous Mu ligand

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11
Q

Dynorphin

A

Endogenous Kappa Ligand

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12
Q

Enkephalin

A

Endogenous Delta ligand

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13
Q

Nalbuphine

A

Mu antagonist
Kappa agonist
injectable form

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14
Q

Buprenorphine

A

Partial Mu agonist
treat severe pain
combined with naloxone to tx dependency

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15
Q

Naloxone

A

Mu Antagonist
short duration
tx- opioid overdose

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16
Q

Naltrexone

A

Opioid Antagonist
long half life
tx alcohol or opiate addiction

17
Q

Dextromethorphan

A

NMDA antagonist

Cough Suppressant

18
Q

Tramadol

A

Weak Mu agonist
Blocks NE and 5-HT uptake
moderate pain

19
Q

Suboxone

A

tx opioid abuse

Pharm Block 3 (10 decks)

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