Antimycobacterials Flashcards

1
Q

Isoniazid

A

inhibit mycolic acid synthesis
Tx- TB
Prodrug activated by KatG and interacts with INH

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2
Q

Rifampin

A

inhibit DNA-dependent RNA poly
tx-TB and leprosy
red color

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3
Q

Ethambutol

A

block cell wall synthesis, arabinosyl transferase

Tuberculostatic

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4
Q

Pyrazinamide

A

block mycolic acid synthesis by Fatty acid synthase I
bacteriosidal
TB

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5
Q

Streptomycin

A

bind to ribosome

Reserved for most serious form of TB

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6
Q

Rifabutin

A

Tx MAC

Rifampin analong

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7
Q

Clarithromycin

A

Tx-MAC

bacteriocidal

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8
Q

Dapsone

A

block folate synthesis via PABA
bacteriostatic
Tx-Leprosy and Pneumocystis jiroveci

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9
Q

Clofazimine

A

bind to DNA interfering with reproduction
causes red brown skin
tx- Leprosy

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