Antimycobacterials Flashcards
1
Q
Isoniazid
A
inhibit mycolic acid synthesis
Tx- TB
Prodrug activated by KatG and interacts with INH
2
Q
Rifampin
A
inhibit DNA-dependent RNA poly
tx-TB and leprosy
red color
3
Q
Ethambutol
A
block cell wall synthesis, arabinosyl transferase
Tuberculostatic
4
Q
Pyrazinamide
A
block mycolic acid synthesis by Fatty acid synthase I
bacteriosidal
TB
5
Q
Streptomycin
A
bind to ribosome
Reserved for most serious form of TB
6
Q
Rifabutin
A
Tx MAC
Rifampin analong
7
Q
Clarithromycin
A
Tx-MAC
bacteriocidal
8
Q
Dapsone
A
block folate synthesis via PABA
bacteriostatic
Tx-Leprosy and Pneumocystis jiroveci
9
Q
Clofazimine
A
bind to DNA interfering with reproduction
causes red brown skin
tx- Leprosy