Antifungal

Question 1

Amphotericin B

Answer 1

effective for most serious systemic mycoses
binds to ergosterol-membrane leakiness via pore
not absorbed
Total cumulative dose
Nephrotoxicity!

Question 2

Flucytosine

Answer 2

5-FU- block Nucleic acid synthesis
tx- Candida, Cryptococcus
given with Amphotericin B to reduce dose
Caution with bone marrow suppression and renal insufficiency pt

Question 3

Fluconazole

Answer 3

Inhibit 14aplha-sterol demethylase. deprives of ergosterol
takes time to go into effect
tx- Cryptococcus and candida(vaginal and UTI)
Urinary and CNS

Question 4

Itraconazole

Answer 4

Inhibit 14aplha-sterol demethylase. deprives of ergosterol
takes time to go into effect
Tx- Blasto, Histo, Candida
Inhibit CYP3A4
toenail infections

Question 5

Voriconazole

Answer 5

Inhibit 14aplha-sterol demethylase. deprives of ergosterol
takes time to go into effect
Tx-Aspergillus, Fusarium, Scedosporium, Candida Krusei
Broad range of azoles
Side effect- Visual disterbances

Question 6

Caspofungin

Answer 6

Block cell wall synthesis via B(1,3)-D-glucan
Tx-Aspergillus, Candida
Phlebitis at injection

Question 7

Miconazole

Answer 7

Inhibit 14aplha-sterol demethylase. deprives of ergosterol
takes time to go into effect
Topical Candida tx

Question 8

Clotrimazole

Answer 8

Inhibit 14aplha-sterol demethylase. deprives of ergosterol
takes time to go into effect
Tx- oral and vaginal Candida

Question 9

Nystatin

Answer 9

Mechanism-make a pore in membrane

Tx- Candida

Question 10

Natamycin

Answer 10

make a ore in the membrane
For fungal Eye infection
used with surgery

Question 11

Tolnaftate

Answer 11

cream or stay/powder
inhibit ergosterol
dermatophytes

Question 12

Terbinafine

Answer 12

topical use for dermatophytes
Oral- nail infections
inhibit fungal squalene epoxidase. damages cell membrane

Question 13

Ciclopirox

Answer 13

Topical Fungal Nail infections

Question 14

Griseofulvin

Answer 14

tx tinea capitis in children

interferes with microtubules