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F2 > Opioides > Flashcards

Opioides Flashcards

1
Q

MA de opioides

A

Agonistas Mu y Kappa

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2
Q

IG de opioides

A

dolor moderado- severo
postquirurgico
oncologíco

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3
Q

FC opioides

A

metabolismo fase 2
conjugación m6g (activo)

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4
Q

EA de opioides

A

Inhibe peristalsis
depression respiratoria
retención urinaria
sedacion

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5
Q

Funcion de los opioides

A

Inhibir Ca+

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6
Q

Opioides Antagonistas NMDA

A

Metadona
mieridona

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7
Q

MA especifico de miperidona

A

Bloquea Na+

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8
Q

IG de antagonistas de NMDA

A

Asociados a dolor neuropatico

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9
Q

MA de tramadol

A

Agonista debil de Mu
Inhibidor de SERT y NET

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10
Q

IG de tramadol

A

Dolor moderado a severo

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11
Q

FC tramadol

A

Interacciones IMAO, ISRS, IRNS

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12
Q

Antagonistas opioides

A

Naloxona
Naltrexone

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13
Q

IG de antagonistas opioides

A

antidoto sobredosis

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14
Q

MA de buprenorfina

A

Agonista Mu
Antagonista kappa

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15
Q

FC de buprenorfina

A

96% biodisponibilidad
alto metabolism 1er paso

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16
Q

Opioides endogenos

A

Enceflinas
endorfinas
dinorfinas

17
Q

MA de receptores Mu

A

inhibicion de canales de Ca2+ activados por voltaje

18
Q

MA de receptores delta

A

Inhibe adenilato ciclasa
Reduce la producción AMPc disminuye la activación PKA

19
Q

Ma de receptores Kappa

A

Hiperpolarizacion mediada por GIRK

20
Q

Efectos que tienen opioides al deprimir neuronas del centros en el tallo cerebral

A

Depression de :
Area inspiratoria
Area pneumotaxica - tos
Area postrema - centro del vomito

21
Q

a nivel periferico que efectos tienen los receptores opioides

A

Inhibe peristalsis
aumenta contracción y tono de músculos del tracto urinario y del iris
liberación de histamina por mastocitos

22
Q

Efecto adverso característico del fentanilo

A

rigid muscular en torax

23
Q

Opioides metalizados por citocromo P450 sustrato CYP2D6

A

codeina
hidrocodona
oxicodonx

24
Q

metabolito activo de codeina

25
Q

Opioides con via de sintesis natural

A

morfina
codeina

26
Q

Opioides con via de sintesis semisintetica

A

buprenorfina
hidromorfina
hidrocodona
oxicodonx
oximorfina

27
Q

Opioides con via de sintesis sintetica

A

fentanyl
meperidona
metadona
tapentadol
tramadol

28
Q

Antagonista parcial

A

bupreneorfina

29
Q

agonista puro debil

A

tramadol
codeina
dihicrocodeina

30
Q

agonista puro potente

A

fentanyl
metadona
oxicodonx
morfina

31
Q

Opioides de potencia debil

A

tramadol
codeina
tapentadol
nalbufina

32
Q

opioides potencia fuerte

A

morfina
oxicodonx
metadona
buprenorfina
fentanyl

33
Q

Unico opioides que no requiere receta medica

F2 (15 decks)

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