antiagregantes Flashcards

1
Q

que hemostasia inhiben los antiagregantes?

A

primaria

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2
Q

pasos de la hemostasia primaria

A

adhesion
activacion
aggregation
forma tapon plaquetario

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3
Q

que ocurre en agregación

A

proteina GP2b/3a sirve de anclaje para fibrinogeno (f1 de coagulación) y forma tapon

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4
Q

Que ocurre en la adhesión

A

endotélio dañado libera F. Von Willebrand
plaquetas por R GP1b se unen al fVW

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5
Q

Que ocurre en la activación

A

plaquetas activadas liberan mas fVW, serotonina, ca+, ADP, tromboxano A2
plaquetas comienzan a expresar GP2b/3a

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6
Q

Aspirina

A

previene trombosis arterial
coadyuvante IAM
AIT y protesis

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7
Q

Dosis de aspirina

A

agudo: 160-325mg
prevención: 75-81mg

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8
Q

EA de aspirina

A

Hemorragia GI

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9
Q

Clopidrogel, prasugel, tigagrelor

A

Bloquean R adenosina difosfato plaquetarios P2Y12

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10
Q

IG e clopidrogel, prasugel y tigagrelor

A

reduce trombosis arterial en px con SCA
prevención secundaria después de MI y EVC

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11
Q

EA de clopidrogrel, prasugrel, ticagrelor

A

aumenta riesgo hemorragia
IBPs disminuyen activación de antiagregantes

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12
Q

MA especifico de Clopidogrel

A

inhibe agregación al ser antagonista de receptor P2Y12

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13
Q

Efecto de aspirina

A

inhibe agregacion al bloquear síntesis de tromboxano A2

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14
Q

MA de Abciximab

A

antihero monoclonal anti gp3b/2a

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15
Q

IG de abciximab

A

previene agregación planetaria/ trombosis px angioplastia

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16
Q

EA de abciximab

A

riesgo de hemorragia

17
Q

MA de tirofiban

A

Antagonista reversible gp3b/2a

18
Q

IG de tirofiban

A

previene trombosis coronaria