Oncology- peds Flashcards

1
Q

TNM staging

A
T= primary tumor 
TX= can't be measured 
T0= can't be found 
Tis= in situ
T1-4= size and spread into structures 
N= lymph nodes
NX= can't be evaluated
N0= no involvement 
N1-3= size, location, and/or number of lymph nodes affected 
M= metastasis 
M0= no distant met
M1= distant met
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2
Q

Acute lymphocytic leukemia (ALL)- epidemiology

A

2-5yr

Most common

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3
Q

Acute lymphocytic leukemia (ALL)- s/s

A
Lymphadenopathy
Fever
Hepatosplenomegaly (HSM)
Fatigue
Pallor
Bruising/bleeding
Bone pain/limp/tenderness
Painless testicular enlargement
Malaise
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4
Q

Acute lymphocytic leukemia (ALL)- dx

A

BMB/A >20%

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5
Q

Acute lymphocytic leukemia (ALL)- labs & imaging

A

CBC w diff and peripheral smear:
Anemia
Thrombocytopenia
Blasts

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6
Q

Acute lymphocytic leukemia (ALL)- tx

A

Chemo- determined by phenotyping

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7
Q

Acute lymphocytic leukemia (ALL)- prognosis

A

5 yr > 85%

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8
Q

CNS tumors- epidemiology

A

2nd most common

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9
Q

CNS tumors- s/s

A
HA
Irritable
N/V
Macrocephaly
Ataxia/impaired gait
Impaired vision
Seizure
Papilledema
Developmental delay
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10
Q

CNS tumors- dx

A

8x- histologic

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11
Q

CNS tumors- labs & imaging

A

MRI

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12
Q

CNS tumors- tx

A

Open surgical procedure - get biopsy and remove as much as possible
Avoid radiation <3yo
Chemo
Anticonvulsants - seizures

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13
Q

CNS tumors- prognosis

A

Depends on tumor type

5y >73%

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14
Q

Retinoblastoma- epidemiology

A

0-2yr

50% heritable - increased chance of passing to kids, and bilateral issues

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15
Q

Retinoblastoma- s/s

A

“Leukocoria

Strabismus, red inflamed eye, nystagmus”

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16
Q

Retinoblastoma- tx

A

REFER TO OPTHO
Get genetic testing

Cryotherapy
Local/systemic Chemo
Laser photocoagulation 
Enucleation
Radiation
17
Q

Retinoblastoma- prognosis

A

> 95%

if untreated- deadly

18
Q

Osteosarcoma- epidemiology

A

Kids - sporadic
Radiation, chemo, genetics, Paget dx - bone breaks down and rebuilds weird
M>F

19
Q

Osteosarcoma- s/s

A

Localized pain - last months

Soft tissue mass on exam - large, TTP

20
Q

Osteosarcoma- dx

A

Biopsy

21
Q

Osteosarcoma- labs & imaging

A

Xray:

  • Destructive lesion
  • Codman triangle - lesion lifts periosteum from bone
  • Sunburst appearance
22
Q

Osteosarcoma- tx

A

Chemo
Preop Chemo -> surgery -> postop chemo
RADIORESISTANT

23
Q

Osteosarcoma- prognosis

A

Depends on tumor response to chemo

24
Q

Ewing sarcoma- epidemiology

A

M>F

10-20yo

25
Q

Ewing sarcoma- s/s

A

Bony pain or swelling- localized months
Limp, fracture
In LONG BONES AND PELVIS

26
Q

Ewing sarcoma- dx

A

Biopsy

27
Q

Ewing sarcoma- labs & imaging

A

Xray:
- Onion peel- periosteal reaction

CT/MRI:

  • show extent of involvement
  • Met w/u
28
Q

Ewing sarcoma- tx

A

Chemo

Surgical resection + radiation

29
Q

Ewing sarcoma- prognosis

A

5y: non-met- 55%

Met- 21%

30
Q

Wilms tumor (Nephroblastoma)- epidemiology

A
Most common renal malignancy 
2-5yo
African
WAGR syndrome
Denys-Drash syndrome
Beckwith-Weidemann syndrome
31
Q

Wilms tumor (Nephroblastoma)- s/s

A

Abdominal mass or swelling- firm, smooth, nontender, unilateral mass
Abdominal pain, hematuria, fever, HTN

32
Q

Wilms tumor (Nephroblastoma)- dx

A

Biopsy

33
Q

Wilms tumor (Nephroblastoma)- labs & imaging

A

Abdominal u/s

34
Q

Wilms tumor (Nephroblastoma)- tx

A

Surgical resection- all
Chemo- some
Radiation- based on stage/ histology