Coag Disorders Flashcards
Hemophilia- description & types
Sex-linked heredity blood disease
Hemophilia A- due to factor VIII deficiency
Hemophilia B- due to factor IX deficiency
- Christmas disease
Hemophilia- s/s- mild, mod & severe
Mild, mod, or severe hemorrhagic disorders
Mild- rare bleeding, disc after excessive bleeding secondary to trauma
Mod- rare bleeding, hemorrhage w trauma
Severe- frequent, spontaneous hemorrhage, early childhood
Bleeding into joints, soft tissue, urine/stool, brain
Hemophilia- labs & imaging
Clotting factor levels- low (diag) CBC- nl Bleeding time- nl PT- nl aPTT- prolonged FVIII/FIX- low
Hemophilia- treatment
PREVENTION
Avoid drugs that interfere w clotting- aspirin, NSAIDS
Prophylaxis prior to surgery- factor replacement
Lifestyle mods- sport?
Early recog of episodes
Blood transfusions
Von Willebrand’s disease- description
Most common congenital
Lack vWF- need for plt adhesion
Von Willebrand’s disease- s/s
Epistaxis Gingival bleeding Menorrhagia GI bleeding Poor bleeding control- surgery, dental
No spontaneous hemorthroses
Von Willebrand’s disease- labs & imaging
Bleeding time- prolonged
VWF- low
Factor VIII- low
Von Willebrand’s disease- Treatment
Little/no tx Avoid ASA Surgery: - Desmopression- release of stored vWF from endothelial cells - Factor VIII- contain vWF
Coagulopathy of liver disease- description
Liver produces all factors except VIII
Coagulopathy of liver disease- labs & imaging
PT/INR
Coagulopathy of liver disease- treatment
FFP transfusions- procedures or bleeding
Vit K deficiency- description
Factor II, VII, IX, X
Vit K deficiency- cause
Malnutrition
Abx- kills flora, no absorption of vit K
Vit K deficiency- s/s
Minor bleeding
Vit K deficiency- labs & imaging
PT- prolonged
aPTT- prolonged
