Oncology

Question 1

Hypercalcemia of squamous cell lung cancer

Answer 1

Production of parathyroid hormone-related peptide (PTH-rP) by malignant cells.
Is structurally homologous to parathyroid hormone and can stimulate PTH receptors, causing symptoms similar to primary hyperparathyroidisim.

Question 2

A non-diabetic patient presenting with acanthosis nigricans, along with gastric complaints and weight loss is most likely suffering from?

Answer 2

Gastric adenocarcinoma.

Question 3

Management of hypercalcemia is?

Answer 3

1. IV fluids
2. A loop diuretic
3. A bisphosphonate for long term calcium control.