Hematology

Question 1

Aplastic crisis vs aplastic anemia

Answer 1

Aplastic crisis: decreased RBC production causing anemia only.
Aplastic anemia: pancytopenia.

Question 2

Chronic Myelogenous Leukemia

Answer 2

Is caused by a balanced translocation of chromosome 9 and 22 resulting in a Philadelphia chromosome (BCR-ABL 1 fusion gene).
Adults less than 50 years of age.
Some patients present with unexplained constitutional symptoms or splenomegaly, but 20% of patients are asymptomatic.

Question 3

Iron deficiency anemia complications

Answer 3

Microcytic, hypochromic anemia and restless legs syndrome

Question 4

TRALI

Answer 4

transfusion-associated lung injury, presents with shortness of breath and pulmonary edema on radiography 30 minutes after transfusion is initiated and occurs secondary to donor antibodies binding recipient leukocytes.