Hematology

Question 1

thrombotic thrombocytopenic purpura pentad.

Answer 1

fever, microangiopathic hemolytic anemia, thrombocytopenia (with associated petechiae), renal dysfunction, and neurological or mental status changes

Question 2

Platelet induced thrombocytopenia

Answer 2

Is a type II hypersensitivity reaction, where antibodies form against and bind to heparin-platelet factor 4 complexes on the surface of platelets.

Question 3

Febrile nonhemolytic transfusion reaction

Answer 3

1-6 hours after a blood transfusion with fever (usually T 38-39 C) and chills.
Is due to the leaking of cyotkines from donor red blood cells due to long periods of storage or by host preformed antibodies to donor white blood cells in the transfusion resulting in a reaction.
The fever often resolves spontaneously within 30 minutes even without treatment