oncology

Question 1

half lives CEA, PSA, AFP

Answer 1

CEA: 18 days
PSA: 18 days
AFP: 5 days

Question 2

most radiosensitive tumors?

Answer 2

seminomas, lymphomas

Question 3

most radioresistant tumors?

Answer 3

epithelial, sarcomas

Question 4

brachytherapy?

Answer 4

radiation source is right next to or IN tumor (Au-198, I-128) for very concentrated doses

Question 5

gamma knife?

Answer 5

cobalt XRT

Question 6

Retinobastoma gene. Rb1

Answer 6

TSG. Ch 13. Cell cycle regulation

Question 7

P53?

Answer 7

TSG. Ch. 17. Controls arrest to apoptosis.

Question 8

APC ?

Answer 8

TSG. Ch 5. Cell cycle regulation.

Question 9

DCC?

Answer 9

TSG. Ch 18. Cell adhesion.

Question 10

Proto oncogenes… ras?

Answer 10

GTPase

Question 11

Src proto-onc?

Answer 11

Tyroskine kinase defect

Question 12

Sis proto-oncogene

Answer 12

PDGF-R defect.

Question 13

Erb B proto onc

Answer 13

EGFR defect

Question 14

Myc proto-onc?

Answer 14

Transcription factors

Question 15

Li-Fraumeni syndrome?

Answer 15

P53 gene defect…
SARCOMA
BREAST
BRAIN
LEUKEMIA
ADRENAL

Question 16

KRAS gene mutation

Answer 16

LUNG
PANCREATIC
COLON

Question 17

Colon ca associated genetic mutations?

Answer 17

APC, p53, DCC, K-ras

Question 18

Virchow’s nodes

Answer 18

Stomach ca related supraclavicular nodes

Question 19

Sister Mary Joseph’s node?

Answer 19

Pancreatic ca related periumbilical node

Question 20

Krukenberg tumor

Answer 20

Stomach cancer to OVARY.

Question 21

type of T cell lymphomas?

Answer 21

HTLV-1 (skin lesions)
Mycosis fungoides (Sezary cells)

Question 22

common chemo regimens
breast
colon
gallbladder ca \
pancreatic

Answer 22

Gemcitabine with cisplatin: gallbladder carcinoma.

Doxorubicin and paclitaxel: breast cancer and sarcoma.
FOLFOX: colorectal cancer.
FOLFIRINOX: pancreatic cancer as neoadjuvant chemotherapy in an attempt to convert the tumor to resectability.

Question 23

retinoblastoma presentation

Answer 23

strabismus, leukocoria, and a white mass on the retina on fundoscopy

Question 24

Von Hippel-Lindau disease

Answer 24

von Hippel-Lindau tumor suppressor gene.

CNS
clear cell renal carcinoma
pheochromocytoma
neuroendocrine tumors of the pancreas.

Question 25

desmoid tumors

Answer 25

stable in size for many years or even spontaneously regress

homogenous on imaging

Bx: reveals bundles of spindle cells and an abundant fibrous stroma

can just watchful wait (image q3 mos MRI)

Question 26

mgmt desmoid tumor that is sx (intraabdominal)

Answer 26

resect en bloc with SBR
if malignant, will need RADIATION.

medical therapy: sulindac and tamoxifen

Question 27

dx of desmoid tumor

Answer 27

because need to rule out like a met.
so image guided core needle bx (no incisional bx because it can seed)
Bx; spindle cell bundles and fibrous stroma

Question 28

MC melanoma sites

Answer 28

skin > eyes > anal *canal (APR)

Question 29

if can’t give octreotide for sx NET, what else

Answer 29

Everolimus