Oncology

Question 1

Which HPV subtypes are carcinogenic?

Answer 1

HPV 33
HPV 16
HPV 18
(16+18 = 34 so 33 and 34)

Question 2

Which are the most common tumours causing bone metastases?

Answer 2

1. Prostate
2. Breast
3. Lung

Question 3

What are the most common sites of bone metastasis?

Answer 3

1. Spine
2. Pelvis
3. Ribs
4. Skull
5. Long bones

Question 4

What are the features of bone mets?

Answer 4

Bone pain
Pathological fractures
Hypercalcaemia
Raised ALP

Question 5

Which cancer is associated with Ca19-9?

Answer 5

Pancreatic

Question 6

Which cancer is associated with CA125?

Answer 6

Ovarian cancer

Question 7

Which cancer is associated with CA15-3?

Answer 7

Breast cancer

Question 8

Which cancer(s) is associated with alpha-feto protein?

Answer 8

Hepatocellular carcinoma
Teratoma

Question 9

Which cancer is associated with carcinoembronic antigen (CEA)?

Answer 9

Colorectal cancer

Question 10

Which cancer is associated with S-100?

Answer 10

Melanoma
Schwannoma

Question 11

Which cancer is associated with bombesin?

Answer 11

Small cell lung carcinoma
Gastric cancer
Neuroblastoma

Question 12

Which chemotherapy agent is associated with hypomagnesaemia?

Answer 12

Cisplatin

Question 13

What should you do when suspecting neoplastic spinal cord compression (inpatient)?

Answer 13

1. High dose oral dex
2. Spinal imaging

Question 14

How should suspected SVC obstruction be managed?

Answer 14

In lung cancer - steroids (then it is usually stented or chemo/radiotherapy is given)
In lymphoma - steroids are harmful
-> if no known malignancy then imaging before steroids

Question 15

Which investigations should be done for all metastatic dx of unknown primary?

Answer 15

FBC, U&Es, LFTs, calcium, urinalysis, LDH
CXR, CT TAP
AFP and HCG

Question 16

Which cytotoxic agent is associated with myelosuppresion, mucositis, liver fibrosis and lung fibrosis?

Answer 16

Methotrexate

Question 17

Which cytotoxic agent is associated with cardiomyopathy?

Answer 17

Doxorubicin

Question 18

investigation for ?paraneoplastic spinal cord compression

Answer 18

MRI WHOLE spine

Question 19

what does a PET scan demonstrate?

Answer 19

glucose uptake
(cancer cells are more metabolically active)

Question 20

follow up investigations to detect testicular teratoma recurrence?

Answer 20

afp and bHCG

Question 21

most common site of bone mets?

Answer 21

spine

Question 22

immediate drug therapy for suspected neoplastic spinal cord compression?

Answer 22

high dose dex