OncoGene/Tumor Supressors Flashcards
BCR-Abl
CML, ALL. Tyrosine Kinase
Bcl-2
Follicular cell and undif lymphoma; Anti-apopotitc molecule
BRAF
Melanoma; Serine/threonin kinase
c-kit
GIST; cytokine receptor (for stem cell factor)
c-myc
Burkitt lymphoma t[8;14]; transcription factor
HER2/neu (c-erbB2)
Breast, ovarain and GI carcinomas; Tyrosine Kinase
L-myc
Lung tumors; transcription factor
N-myc
Neuroblastoma of adrneals; transcription factor
ras
colon cancer, lung cancer panc cancer; GTPase
ret
MEN2a/b, autodom; tyrosine kinase
APC
Colorectal cacner (FAP)
BRCA1/2
Breast and ovarian cancer; DNA repair protein
CPD4/SMAD4
Panc Cancer; DPC (DELETED IN PANC CANCER)
DCC
Colon Cancer (DCC=DELEETED IN COLON CNACER)
MEN1
MEN type 1
NF1
NF1: Chromo 17, RAS GTPase activating protein (neurfibromin)
NF2
Chromo 22; Merlin (schwannomin) protein
p16
Melanoma; CDK inhibitor 2a
p53
Liframunei, most cancers; Transcription factor for p21 which blocks G1–>S phase (and interacts with RB!)
PTEN
Breast cacner, porstate cancer, endometrial cacner
Rb
Retinoblastoma AND osteosarcoma; inhibits E2F blocking G1–>S
TSC1 TSC2
Harmartin, TSC2=Tuberin protein
VHL
von hippel-lindua; inhibits hypoxia inducible factor 1a (thus vascular type cancers)
WT1/2
Wilms Tumor (nephroblastoma)
Alk phosph
Mets to bone, liver, paget disase of bone, seminoma (placental ALP)
Alpha fetoprotein
HCC, Hepatoblaomsta, yolk sac (endodermal sinus) tumor, testuclar cancer, mixed germ cell tumor
BhCG
Hydatidiform moles and choriocarciomas, testicular cancer
CA-15-3/CA-27-29
Breast Cancer
CA-19-9
Panc Adenocarcinoma
CA-125
Ovarian Cancer
Calcitonin
Meudllary THyroid carcioma
CEA
CarcinoEmbryonic Antigen. Colorectal, panc. Also in some gastric, breast and medullarythyroid carniomas
S-100
Neural Crest origin (melanomas, Neural tuomr,schwannoams, Langerhan cell hstiocytosis)
TRAP
Hairy cell luekmia