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CK Heme Onc > Onc 3 > Flashcards

Onc 3 Flashcards

1
Q

CN responsible for:

eye lid openning

A

3

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2
Q

CN responsible for:

taste in ant 2/3

A

7

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3
Q

CN responsible for:

head turning

A

11

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4
Q

CN responsible for:

tongue movement

A

12

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5
Q

CN responsible for:

mastication

A

5

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6
Q

CN responsible for:

balance

A

8

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7
Q

CN responsible for:

carotid body/sinus

A

9

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8
Q

CD marker a/w:

Th

A

4

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9
Q

CD marker a/w:

Tc

A

8

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10
Q

CD marker a/w:

all T cells

A

2,3

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11
Q

CD marker a/w:

B cells

A

19,20,21

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12
Q

CD marker a/w:

NK and binds to constant region of IgG

A

16

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13
Q

CD marker a/w:

inhibits complemet C9

A

55

59

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14
Q

CD marker a/w:

endotoxin receptor on macrophages

A

14

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15
Q

molecule that binds to fibrin

A

Gp 2b3a

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16
Q

molecule that binds to vWF

A

Gp1b

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17
Q

immune cells involved in killing cancer cells

A

NK

Tc

macrophages

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18
Q

what enzyme present in melanoma generates peptides that are targets for host T cells

A

tyrosinase

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19
Q

how can tumor cells evade Tc

A

loss of MHC1

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20
Q

how can tumor cells induce apoptosis of T cells

A

induce FasL

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21
Q

symptoms of inhibiting parasympathetic

A 
dry
red
hot
mad
bloated
blind
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22
Q

tumor marker:

PSA

A

prostate

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23
Q

tumor marker:

AFP

A

HCC

yolk sac

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24
Q

tumor marker:

CA 125

A

ovarian

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25
Q

tumor marker:

alk phosph

A

biliary

bone

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26
Q

tumor marker:

CEA

A

colon

pancreatic

stomach

breast

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27
Q

tumor marker:

bHCG

A

choriocarcinoma

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28
Q

tumor marker:

S100

A

melanoma

astrocytoma

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29
Q

treatment for:

giardia,entameoba, trichomonas

A

metro

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30
Q

treatment for:

vivax/ovale

A

chloroquine

primaquine

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31
Q

treatment for:

flukes, tapeworms

A

praziquantel

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32
Q

treatment for:

worms

A

bendazoles

pyrantel pamoate

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33
Q

chemo:

nitrogen mustard, alkylates DNA

A

cyclophosphamide

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34
Q

chemo:

mechanism similar to antivirals acyclovir and foscarnet

A

cytarabine

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35
Q

chemo:

free radical induced DNA breakage

A

blemycin

-rubacin

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36
Q

Rx for choriocarcinoma

A

methotrexate

vincristin/blastin

37
Q

Rx for AML

A

cytarabine

38
Q

Rx for CML

A

imatinib

busulfan

39
Q

MOA of tituximab

A

monoclonal antibody vs CD20

40
Q

SE of imatinib

A

fluid retention

41
Q

SE of trastuzumab

A

cardiotoxicity

42
Q

MOA of bortezomib

A

proteasome inhibitor

43
Q

Rx for MM

A

bortezomib

44
Q

Rx for hairy cell leukemia

A

cladribine

45
Q

what drugs cause nephrotoxicity and ototoxicity

A

-platins

vancomycin

aminoglycosides

loops

46
Q

how do you prevent nephrotoxicity caused by

-platins

A

amifostine

47
Q

MOA of -platins

A

cross link DNA

48
Q

what drugs work on the M phase

A

vincristin/blastin

-taxols

49
Q

SE of vincristine

A

neurotoxicity

50
Q

SE of vinblastin

A

BM suppression

51
Q

how do you prevent cardiotoxicity caused by

-rubacin

A

dexrazoxane

52
Q

MOA of dexrazoxane

A

iron chelating agent

53
Q

how does -rubacin cause cardiotoxicity

A

cardiac fibrosis

-dilated cardiomyopathy

54
Q

Rx for testicular cancer

A

etoposide

bleomycin

cisplatin

55
Q

MOA of busulfan

A

alkylates DNA

56
Q

MOA of cyclophosphamide

A

covalently X link DNA at the guanine N-7

57
Q

what is required for cyclophosphamide to work

A

biactivation by liver

58
Q

what causes the heorrhagic cystitis by cyclophosphamides

A

toxic metabolites

-Acrolein

59
Q

SE of cyclophosphamide

A

hemorrhagic cystitis

transitional cell carcinoma of the bladder

SIADH

60
Q

MOA of bleomycin

A

induces free radicals which break DNA strand

61
Q

MOA -rubacin

A

generates free radicals which intercalate DNA

62
Q

MOA of dactinomycin

A

intercalates DNA

63
Q

MOA of cytarabine

A

inhibits DNA polymerase

64
Q

5FU can be used to Rx

A

actinic keratosis

basal cell carcinoma

65
Q

Rx for 5FU toxicity

A

thymidine

66
Q

Rx for MTX toxicity

A

leucovorin

-folinic acid

67
Q

what drugs inhibit DHF reductase

A

MTX

TMP

pyrimethamine

68
Q

what drugs work in G2

A

bleomycin

etoposide

69
Q

what drugs work in the S phase

A

MTX

6MP/TG

5FU

cytarabine

etoposide

70
Q

CN responsible for:

eye lid openning

A

3

71
Q

CN responsible for:

taste in ant 2/3

A

7

72
Q

CN responsible for:

head turning

A

11

73
Q

CN responsible for:

tongue movement

A

12

74
Q

CN responsible for:

mastication

A

5

75
Q

CN responsible for:

balance

A

8

76
Q

CN responsible for:

carotid body/sinus

A

9

77
Q

CD marker a/w:

Th

A

4

78
Q

CD marker a/w:

Tc

A

8

79
Q

CD marker a/w:

all T cells

A

2,3

80
Q

CD marker a/w:

B cells

A

19,20,21

81
Q

CD marker a/w:

NK and binds to constant region of IgG

A

16

82
Q

CD marker a/w:

inhibits complemet C9

A

55

59

83
Q

CD marker a/w:

endotoxin receptor on macrophages

A

14

84
Q

molecule that binds to fibrin

A

Gp 2b3a

85
Q

molecule that binds to vWF

A

Gp1b

86
Q

immune cells involved in killing cancer cells

A

NK

Tc

macrophages

87
Q

what enzyme present in melanoma generates peptides that are targets for host T cells

A

tyrosinase

88
Q

how can tumor cells evade Tc

A

loss of MHC1

89
Q

how can tumor cells induce apoptosis of T cells

A

induce FasL

CK Heme Onc (13 decks)

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