Onc 3 Flashcards
1
Q
CN responsible for:
eye lid openning
A
3
2
Q
CN responsible for:
taste in ant 2/3
A
7
3
Q
CN responsible for:
head turning
A
11
4
Q
CN responsible for:
tongue movement
A
12
5
Q
CN responsible for:
mastication
A
5
6
Q
CN responsible for:
balance
A
8
7
Q
CN responsible for:
carotid body/sinus
A
9
8
Q
CD marker a/w:
Th
A
4
9
Q
CD marker a/w:
Tc
A
8
10
Q
CD marker a/w:
all T cells
A
2,3
11
Q
CD marker a/w:
B cells
A
19,20,21
12
Q
CD marker a/w:
NK and binds to constant region of IgG
A
16
13
Q
CD marker a/w:
inhibits complemet C9
A
55
59
14
Q
CD marker a/w:
endotoxin receptor on macrophages
A
14
15
Q
molecule that binds to fibrin
A
Gp 2b3a
16
Q
molecule that binds to vWF
A
Gp1b
17
Q
immune cells involved in killing cancer cells
A
NK
Tc
macrophages
18
Q
what enzyme present in melanoma generates peptides that are targets for host T cells
A
tyrosinase
19
Q
how can tumor cells evade Tc
A
loss of MHC1
20
Q
how can tumor cells induce apoptosis of T cells
A
induce FasL
21
Q
symptoms of inhibiting parasympathetic
A
dry red hot mad bloated blind
22
Q
tumor marker:
PSA
A
prostate
23
Q
tumor marker:
AFP
A
HCC
yolk sac
24
Q
tumor marker:
CA 125
A
ovarian
25
tumor marker:
| alk phosph
biliary
bone
26
tumor marker:
| CEA
colon
pancreatic
stomach
breast
27
tumor marker:
| bHCG
choriocarcinoma
28
tumor marker:
| S100
melanoma
astrocytoma
29
treatment for:
| giardia,entameoba, trichomonas
metro
30
treatment for:
| vivax/ovale
chloroquine
primaquine
31
treatment for:
| flukes, tapeworms
praziquantel
32
treatment for:
| worms
bendazoles
pyrantel pamoate
33
chemo:
| nitrogen mustard, alkylates DNA
cyclophosphamide
34
chemo:
| mechanism similar to antivirals acyclovir and foscarnet
cytarabine
35
chemo:
| free radical induced DNA breakage
blemycin
-rubacin
36
Rx for choriocarcinoma
methotrexate
vincristin/blastin
37
Rx for AML
cytarabine
38
Rx for CML
imatinib
busulfan
39
MOA of tituximab
monoclonal antibody vs CD20
40
SE of imatinib
fluid retention
41
SE of trastuzumab
cardiotoxicity
42
MOA of bortezomib
proteasome inhibitor
43
Rx for MM
bortezomib
44
Rx for hairy cell leukemia
cladribine
45
what drugs cause nephrotoxicity and ototoxicity
-platins
vancomycin
aminoglycosides
loops
46
how do you prevent nephrotoxicity caused by
| -platins
amifostine
47
MOA of -platins
cross link DNA
48
what drugs work on the M phase
vincristin/blastin
-taxols
49
SE of vincristine
neurotoxicity
50
SE of vinblastin
BM suppression
51
how do you prevent cardiotoxicity caused by
| -rubacin
dexrazoxane
52
MOA of dexrazoxane
iron chelating agent
53
how does -rubacin cause cardiotoxicity
cardiac fibrosis
| -dilated cardiomyopathy
54
Rx for testicular cancer
etoposide
bleomycin
cisplatin
55
MOA of busulfan
alkylates DNA
56
MOA of cyclophosphamide
covalently X link DNA at the guanine N-7
57
what is required for cyclophosphamide to work
biactivation by liver
58
what causes the heorrhagic cystitis by cyclophosphamides
toxic metabolites
| -Acrolein
59
SE of cyclophosphamide
hemorrhagic cystitis
transitional cell carcinoma of the bladder
SIADH
60
MOA of bleomycin
induces free radicals which break DNA strand
61
MOA -rubacin
generates free radicals which intercalate DNA
62
MOA of dactinomycin
intercalates DNA
63
MOA of cytarabine
inhibits DNA polymerase
64
5FU can be used to Rx
actinic keratosis
basal cell carcinoma
65
Rx for 5FU toxicity
thymidine
66
Rx for MTX toxicity
leucovorin
| -folinic acid
67
what drugs inhibit DHF reductase
MTX
TMP
pyrimethamine
68
what drugs work in G2
bleomycin
etoposide
69
what drugs work in the S phase
MTX
6MP/TG
5FU
cytarabine
etoposide
70
CN responsible for:
| eye lid openning
3
71
CN responsible for:
| taste in ant 2/3
7
72
CN responsible for:
| head turning
11
73
CN responsible for:
| tongue movement
12
74
CN responsible for:
| mastication
5
75
CN responsible for:
| balance
8
76
CN responsible for:
| carotid body/sinus
9
77
CD marker a/w:
| Th
4
78
CD marker a/w:
| Tc
8
79
CD marker a/w:
| all T cells
2,3
80
CD marker a/w:
| B cells
19,20,21
81
CD marker a/w:
| NK and binds to constant region of IgG
16
82
CD marker a/w:
| inhibits complemet C9
55
59
83
CD marker a/w:
| endotoxin receptor on macrophages
14
84
molecule that binds to fibrin
Gp 2b3a
85
molecule that binds to vWF
Gp1b
86
immune cells involved in killing cancer cells
NK
Tc
macrophages
87
what enzyme present in melanoma generates peptides that are targets for host T cells
tyrosinase
88
how can tumor cells evade Tc
loss of MHC1
89
how can tumor cells induce apoptosis of T cells
induce FasL
