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CK Heme Onc > Heme 1 > Flashcards

Heme 1 Flashcards

1
Q

RLS in:

glycolysis

A

PFK 1

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2
Q

RLS in:

gluconeogenesis

A

F16BP

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3
Q

RLS in:

TCA

A

isocitrate DH

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4
Q

RLS in:

glycogen synthesis

A

glycogen synthase

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5
Q

RLS in:

glycogenolysis

A

glycogen phosphorylase

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6
Q

Diabetic drug:

lactic acidosis

A

metformin

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7
Q

Diabetic drug:

SE of hypoglycemia

A

sulfonureas

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8
Q

Diabetic drug:

MOA closes K channels

A

sulfonureas

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9
Q

Diabetic drug:

inhibits a-glucosidase

A

acarbose

miglitol

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10
Q

Diabetic drug:

agonist at PPAR-y

A

TZD

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11
Q

what anticoagulant factors are dependent on vitamin K

A

S

C

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12
Q

what coagulant factors are dependent on vitamin K

A

10
9
7
2

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13
Q

effects of bradykinen

A

vasodilate

inc vascular permeability

inc pain

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14
Q

labs used to monitor:

warfarin

A

PT

INR

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15
Q

labs used to monitor:

heparin

A

PTT

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16
Q

labs used to monitor:

enoxaparin

A

factor 10a activity

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17
Q

Rx for HIT

A

lapirudin

bivalirudin

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18
Q

what mineral is needed for coagulation

A

Ca

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19
Q

what can cause a decrease in Ca coagulation

A

citrate

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20
Q

in liver failure, which factor is lost first

A

7

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21
Q

MOA of acute hemolytic transfusion reaction

A

recurrent meningiococcal infection due to hyperstabalized C3

deficiency on properdin
-would normally cleave C3

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22
Q

symptoms of clotting factor defect

A

bleeding

hemarthrosis

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23
Q

symptoms of platelet defect

A

patechiae

24
Q

what stimulates the release of factor 8 and vWF form endothelial cells

A

desmopressin

25
Q

main symptom of hemophilia

A

hemarthrosis

26
Q

lab changes in hemophilia

A

inc PTT

27
Q

lab changes in vitamin K def

A

inc PT and PTT

28
Q

prothrombin gene mutation

A

G20210A

29
Q

what does AT3 normally activate

A 
7
9
10
11
12
30
Q

heparin given to AT3 def px

A

reduced inc in PTT

31
Q

MOA of acute hemolytic transfusion reaction

A

recurrent meningiococcal infection due to hyperstabalized C3

deficiency on properdin
-would normally cleave C3

32
Q

symptoms of clotting factor defect

A

bleeding

hemarthrosis

33
Q

symptoms of platelet defect

A

patechiae

34
Q

what stimulates the release of factor 8 and vWF form endothelial cells

A

desmopressin

35
Q

main symptom of hemophilia

A

hemarthrosis

36
Q

lab changes in hemophilia

A

inc PTT

37
Q

lab changes in vitamin K def

A

inc PT and PTT

38
Q

prothrombin gene mutation

A

G20210A

39
Q

what does AT3 normally activate

A 
7
9
10
11
12
40
Q

heparin given to AT3 def px

A

reduced inc in PTT

41
Q

liver makes all clotting factors except

A

vWF

42
Q

D-dimers rise from the break down of

A

fibrin

43
Q

FDP rise from the break down of

A

fibrin or fibrinogen

44
Q

MOA of enoxaparin

A

inhibit factor 10a

45
Q

MOA of heparin

A

increase activation of AT

46
Q

MOA of HIT

A

heparin binds to platelet factor 4 causing antibody production

47
Q

why are px with HIT hypercoagulable

A

platelets are dropped but remaining ones are hyperactive

48
Q

MOA of argatroban

A

directly inhibits thrombin

49
Q

when is lepirudin used

A

px who take heparin and develops HIT

50
Q

MOA of warfarin

A

inhibits epoxide reductase
-normally recycles vit K

no more y-carboxylation of factors

51
Q

what labs change with thrombolytics

A

inc PT and PTT

52
Q

what is used in atrial fib

A

warfarin

53
Q

what is used in STEMI

A

thrombolytics

54
Q

MOA of thrombolytics

A

increase conversion of plasminogen to plasmin

55
Q

name some thrombolytics

A

streptokinase

urokinase

alteplase (tPA)

APSAC (anistreplase)

56
Q

how does aminocaproic acid work

A

inhibits fibrinolysis

CK Heme Onc (13 decks)

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