Heme 5

Question 1

what enzyme catalyzes peptide bond formation

Answer 1

peptidyl transferase

ribozyme

Question 2

what conditions are a/w target cells

Answer 2

HbC
Asplenia
Liver disease
Thalassemia

Question 3

name given to anemia caused by aortic stenosis or prosthetics

Answer 3

macroangiopathic anemia

Question 4

who synthesizes vWF

Answer 4

endothelial cells

megakaryocytes

Question 5

what are the functions of vWF

Answer 5

stabalizes factor 8
-def causes inc PTT

adhesion to vessel wall
-def causes inc BT

Question 6

what is the cause of ITP

Answer 6

auto Gp2b3a Ab

Question 7

what is the cause of bernard soulier

Answer 7

def in Gp1b

Question 8

life span of a platelet

Answer 8

8-10 days

Question 9

what is expressed on platelets after activation

Answer 9

Gp 2b3a

Question 10

MOA of:

streptokinase

Answer 10

increase plasmin

Question 11

MOA of:

aspirin

Answer 11

irreversible inhibits COX 1 and 2

Question 12

MOA of:

clopidogrel

Answer 12

inhibits ADP receptor

Question 13

MOA of:

abciximab

Answer 13

inhibits Gp 2b3a

Question 14

MOA of:

tirofiban

Answer 14

inhibits Gp2b3a

Question 15

MOA of:

ticlopidine

Answer 15

inhibits ADP receptor

Question 16

MOA of:

enoxaparin

Answer 16

LMWH

Question 17

MOA of:

eptifibatide

Answer 17

inhibits Gp 2b3a

Question 18

lab findings in DIC

Answer 18

increased PT, PTT, BT, D dimers

decreased PC, fibrinogen, 5, 8

Question 19

where are platelets stored

Answer 19

spleen

Question 20

what is the vWF receptor on platelets

Answer 20

Gp1b

Question 21

what is the fibrinogen receptor on platelets

Answer 21

Gp2b3a

Question 22

disorder with a defect in platelet adhesion

Answer 22

bernard soulier

Question 23

disorder with a defect in platelet aggregation

Answer 23

glanzmann

Question 24

Rx for ITP

Answer 24

steroids

removal of spleen

Question 25

labs in ITP

Answer 25

increased megakaryocytes

Question 26

defect in TTP

Answer 26

ADAMTS 13

vWF metalloprotease

Question 27

labs in TTP

Answer 27

schistocytes

inc LDH

Question 28

symptoms on HUS

Answer 28

preceeded by bloody diarrhea
usually EHEC

hemolysis
uremia (kidney failure)
thrombocytopenia

Question 29

symptoms on TTP

Answer 29

HUS +
fever
neuro problem

Question 30

Dx of vW disease

Answer 30

ristocetin test

Question 31

Rx for vW disease

Answer 31

DDAVP (desmopressin)

Question 32

where are vWF stored

Answer 32

Weibel Palade bodies

Question 33

causes of DIC

Answer 33

Sepsis
Trauma
Obstetrics
Pancreatitis
Malignancy
Nephrotic syndrome
Transfusion

Question 34

when should you expect DIC

Answer 34

px with inc PT and PTT

Question 35

what must be monitored in DIC

Answer 35

fibrinogen

Question 36

which platelet disorder has a normal PC

Answer 36

glanzmanns