Heme 5 Flashcards
what enzyme catalyzes peptide bond formation
peptidyl transferase
ribozyme
what conditions are a/w target cells
HbC
Asplenia
Liver disease
Thalassemia
name given to anemia caused by aortic stenosis or prosthetics
macroangiopathic anemia
who synthesizes vWF
endothelial cells
megakaryocytes
what are the functions of vWF
stabalizes factor 8
-def causes inc PTT
adhesion to vessel wall
-def causes inc BT
what is the cause of ITP
auto Gp2b3a Ab
what is the cause of bernard soulier
def in Gp1b
life span of a platelet
8-10 days
what is expressed on platelets after activation
Gp 2b3a
MOA of:
streptokinase
increase plasmin
MOA of:
aspirin
irreversible inhibits COX 1 and 2
MOA of:
clopidogrel
inhibits ADP receptor
MOA of:
abciximab
inhibits Gp 2b3a
MOA of:
tirofiban
inhibits Gp2b3a
MOA of:
ticlopidine
inhibits ADP receptor
MOA of:
enoxaparin
LMWH
MOA of:
eptifibatide
inhibits Gp 2b3a
lab findings in DIC
increased PT, PTT, BT, D dimers
decreased PC, fibrinogen, 5, 8
where are platelets stored
spleen
what is the vWF receptor on platelets
Gp1b
what is the fibrinogen receptor on platelets
Gp2b3a
disorder with a defect in platelet adhesion
bernard soulier
disorder with a defect in platelet aggregation
glanzmann
Rx for ITP
steroids
removal of spleen
