Onc 1 Flashcards by Mani Yavi

Q

protozoa a/w:

chagas

A

t cruzi

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Q

protozoa a/w:

vaginitis

A

trichomonas

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Q

protozoa a/w:

malaria

A

plasmodium

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Q

protozoa a/w:

birth defects

A

toxoplasmsois

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Q

protozoa a/w:

bloody diarrhea

A

e histolytica

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Q

protozoa a/w:

diarrhea, flatulence, bloating

A

g lamblia

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Q

how does p53 induce apoptosis

A

induces transcription of pro-apoptotic genes, such as BAX

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Q

cancers a/w:

K-RAS

A

colon

lung

pancreatic

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Q

cancers a/w:

H-RAS

A

bladder

kidney

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Q

cancers a/w:

N-RAS

A

melanoma

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Q

cancers a/w:

Rb

A

Rb

osteosarcoma

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Q

cancers a/w:

DPC

A

pancreatic

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Q

cancers a/w:

APC

A

FAP

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Q

cancers a/w:

WT1

A

wilms

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Q

cancers a/w:

BRCA

A

breast

ovarian

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Q

cancers a/w:

arsenic

A

lung

skin

hemangiosarcoma

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Q

cancers a/w:

benzene

A

leukemia

hodgkins

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Q

cancers a/w:

beryllium

A

lung

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Q

cancers a/w:

cadmium

A

prostate

lung

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Q

cancers a/w:

chromium

A

lung

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Q

cancers a/w:

nickel sulfate

A

lung

Q

cancers a/w:

radon

A

lung

Q

cancers a/w:

ionizing radiation

A

AML/CML

thyroid cancer

Q

cancers a/w:

UV exposure

A

SCC

basal cell carcinoma

melanoma

what UV type is most problematic

B causes pyrimidine dimers

cancers a/w: | mismatch repair defect

HNPCC

cancers a/w: | excision repair defect

XP

cancers a/w: | s bovis

colon

cancers a/w: | h pylori

gastric

cancers a/w: | schistosoma

SCC of the bladder

cancers a/w: | c sinensis

biliary carcinoma

cancers a/w: | hashimoto

lymphoma

cancers a/w: | downs

ALL/AML

cancers a/w: | plummer vinson

SCC of the esophagus

cancers a/w: | tuberous sclerosis

rabdomyoma astrocytoma angiomyolipoma

cancers a/w: | ataxia telangiectasia

lymphoma leukemia

cancers a/w: | pagets

osteosarcoma

cancers a/w: | nitrosamines

esophageal stomach colon

cancers a/w: | asbestos

mesothelioma bronchiogenic carcinoma

cancers a/w: | naphthalene

transitional cell bladder cancer

cancers a/w: | arsenic

angiosarcoma SCC of the skin

cancers a/w: | EBV

nasopharyngeal hodgkins burkitts

what is required to phosphorylate Rb

cyclin D binding to CDK4

what inhibits CDK4

p53

what must happen for tumor suppressor genes to cause cancer

both alleles must be lost

what must happen for oncogenes to cause cancer

damage to 1 allele

which oncogenes code for tyrosine kinase

ret erb-B2 abl

which oncogenes code for transcription factor

myc's c-myc l-myc n-myc

cancers a/w: | aflatoxin of aspergillous

HCC

cancers a/w: | vinyl chloride

angiosarcoma