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CK Heme Onc > Heme 6 > Flashcards

Heme 6 Flashcards

1
Q

what will be seen on urinalysis of MM

A

nothing

must use UPEP to see bence jones protein

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2
Q

Leukemia:

MC in children

A

ALL

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3
Q

Leukemia:

MC in adults

A

CLL

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4
Q

Leukemia:

AML a/w downs

A

M7

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5
Q

Leukemia:

AML a/w CD 13 and 33

A

M0-M6

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6
Q

Leukemia:

auer rods

A

AML (M2-M3)

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7
Q

myelodysplastic syndromes progress to

A

AML

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8
Q

myeloproliferative disease progress to

A

AML

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9
Q

Leukemia:

AML that is CD 41 and 61 positive

A

M7

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10
Q

Leukemia:

PAS positive

A

ALL

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11
Q

Leukemia:

bone pain

A

ALL

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12
Q

Leukemia:

equivalent to burketts

A

ALL (L3 or B)

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13
Q

Leukemia:

increased basophils, splenomegaly, negative LAP

A

CML

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14
Q

Leukemia:

MC in neonates

A

AML (M7)

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15
Q

Leukemia:

always has philadelphia chromosome

A

CML

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16
Q

Leukemia:

AML negative CD 13 and 33

A

AML (M7)

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17
Q

Leukemia:

positive for peroxidase

A

AML

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18
Q

Leukemia:

solid sheets of lymphoblasts in marrow

A

ALL

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19
Q

Leukemia:

PAS negative

A

AML

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20
Q

Leukemia:

always a/w BCR-ABL

A

CML

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21
Q

neoplasms a/w AIDS

A

squamous (HPV)

karposi

lymphoma

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22
Q

MC bleeding disorder

A

vW disease

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23
Q

cancer a/w hashimoto

A

marginal cell lymphoma

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24
Q

hematologic disease:

MC lymphoma

A

diffuse large B cell lymphoma

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25
Q

hematologic disease:

reed sternberg

A

hodgkin

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26
Q

hematologic disease:

a/w EBV

A

hodgkins

burkitts

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27
Q

hematologic disease:

a/w long term celiac disease

A

intestinal T cell lymphoma

28
Q

hematologic disease:

lymphoma equivalent to CLL

A

small lymphocytic lymphoma

29
Q

hematologic disease:

starry night pattern

A

burkitts

30
Q

what causes the starry night appearance in burkitts

A

phagocytosis of apoptotic tumor cells

31
Q

hematologic disease:

a/w sjogren, hashimoto, H pylori

A

marginal cell MALToma

32
Q

MC non hodgkin in adults

A

diffuse large B cell

33
Q

MC non hodgkin in children

A

lymphoblastic lymphoma

34
Q

lymphoma presentation

A

painless lymphadenopathy

fever
weight loss
night sweats

35
Q

what is used to prevent nephropathy when treating leukemia/lymphoma

A

xanthine oxidase inhibitors

allopurinal
febuxostat

36
Q

CD markers for RS cells

A

CD 30 and 15

37
Q

MC hodgkins lymphoma

A

nodular sclerosing

38
Q

hodgkins lymphoma a/w lots of RS cells

A

mixed cellularity

39
Q

cytokines produced by RS cells affect

A

podocytes

-leading to minimal change dz

40
Q

translocation in:

burkitts

A

8:14

41
Q

translocation in:

mantle cell

A

11:14

42
Q

translocation in:

follicular

A

14:18

43
Q

translocation in:

AML

A

15: 17
8: 21

44
Q

CD marker in smudge cells

A

19 and 20

45
Q

AML with gum infiltration

A

M2

46
Q

how can you differentiate CML from leukomoid reaction

A

CML = low LAP

leukomoid = high LAP

47
Q

mutation in CML

A

PDGF

48
Q

translocation in:

CML

A

9:22

49
Q

mutation in AML

A

retinoic acid

50
Q

how do you stain auer rods

A

myeloperoxidase

51
Q

Rx for AML

A

all trans retinoic acid

52
Q

Rx for CML

A

imatinib

53
Q

Rx for hairy cell leukemia

A

cladribine

54
Q

stain for hairy cell leukemia

A

TRAP

55
Q

a/w with smudge cells

A

CLL

56
Q

Rx for MM and waldetnstrom

A

bortezomib

57
Q

MOA of bortezomib

A

proteasome inhibitor

58
Q

symptoms of MM

A 
hypercalcemia
rouleoux formation
amyloidosis (AL)
bence jones
bone lesions
anemia
renal insufficiency
59
Q

Ig a/w MM

A

IgG and IgA

60
Q

Ig a/w waldenstrom

A

IgM

61
Q

differentiate MM from waldenstrom

A

waldenstrom

  • IgM
  • hyperviscosity
  • no bone lesions
62
Q

a/w painless lymph node involvement that fluctuates

A

follicular lymphoma

63
Q

cells found in the follicular lymphoma

A

centrocytes

-small cleaved cells

64
Q

mutation in follicular lymphoma

A

bcl-2

65
Q

what can cause adult t cell lymphoma

A

HTLV-1

66
Q

mutation in burkits

A

c-myc

67
Q

a/w with deactivation of cyclin D

A

mantle cell lymphoma

CK Heme Onc (13 decks)

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