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CK Heme Onc > Heme 6 > Flashcards

Heme 6 Flashcards

1
Q

what will be seen on urinalysis of MM

A

nothing

must use UPEP to see bence jones protein

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2
Q

Leukemia:

MC in children

A

ALL

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3
Q

Leukemia:

MC in adults

A

CLL

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4
Q

Leukemia:

AML a/w downs

A

M7

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5
Q

Leukemia:

AML a/w CD 13 and 33

A

M0-M6

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6
Q

Leukemia:

auer rods

A

AML (M2-M3)

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7
Q

myelodysplastic syndromes progress to

A

AML

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8
Q

myeloproliferative disease progress to

A

AML

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9
Q

Leukemia:

AML that is CD 41 and 61 positive

A

M7

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10
Q

Leukemia:

PAS positive

A

ALL

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11
Q

Leukemia:

bone pain

A

ALL

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12
Q

Leukemia:

equivalent to burketts

A

ALL (L3 or B)

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13
Q

Leukemia:

increased basophils, splenomegaly, negative LAP

A

CML

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14
Q

Leukemia:

MC in neonates

A

AML (M7)

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15
Q

Leukemia:

always has philadelphia chromosome

A

CML

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16
Q

Leukemia:

AML negative CD 13 and 33

A

AML (M7)

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17
Q

Leukemia:

positive for peroxidase

A

AML

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18
Q

Leukemia:

solid sheets of lymphoblasts in marrow

A

ALL

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19
Q

Leukemia:

PAS negative

A

AML

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20
Q

Leukemia:

always a/w BCR-ABL

A

CML

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21
Q

neoplasms a/w AIDS

A

squamous (HPV)

karposi

lymphoma

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22
Q

MC bleeding disorder

A

vW disease

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23
Q

cancer a/w hashimoto

A

marginal cell lymphoma

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24
Q

hematologic disease:

MC lymphoma

A

diffuse large B cell lymphoma

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25
hematologic disease: | reed sternberg
hodgkin
26
hematologic disease: | a/w EBV
hodgkins burkitts
27
hematologic disease: | a/w long term celiac disease
intestinal T cell lymphoma
28
hematologic disease: | lymphoma equivalent to CLL
small lymphocytic lymphoma
29
hematologic disease: | starry night pattern
burkitts
30
what causes the starry night appearance in burkitts
phagocytosis of apoptotic tumor cells
31
hematologic disease: | a/w sjogren, hashimoto, H pylori
marginal cell MALToma
32
MC non hodgkin in adults
diffuse large B cell
33
MC non hodgkin in children
lymphoblastic lymphoma
34
lymphoma presentation
painless lymphadenopathy fever weight loss night sweats
35
what is used to prevent nephropathy when treating leukemia/lymphoma
xanthine oxidase inhibitors allopurinal febuxostat
36
CD markers for RS cells
CD 30 and 15
37
MC hodgkins lymphoma
nodular sclerosing
38
hodgkins lymphoma a/w lots of RS cells
mixed cellularity
39
cytokines produced by RS cells affect
podocytes | -leading to minimal change dz
40
translocation in: | burkitts
8:14
41
translocation in: | mantle cell
11:14
42
translocation in: | follicular
14:18
43
translocation in: | AML
15: 17 8: 21
44
CD marker in smudge cells
19 and 20
45
AML with gum infiltration
M2
46
how can you differentiate CML from leukomoid reaction
CML = low LAP leukomoid = high LAP
47
mutation in CML
PDGF
48
translocation in: | CML
9:22
49
mutation in AML
retinoic acid
50
how do you stain auer rods
myeloperoxidase
51
Rx for AML
all trans retinoic acid
52
Rx for CML
imatinib
53
Rx for hairy cell leukemia
cladribine
54
stain for hairy cell leukemia
TRAP
55
a/w with smudge cells
CLL
56
Rx for MM and waldetnstrom
bortezomib
57
MOA of bortezomib
proteasome inhibitor
58
symptoms of MM
``` hypercalcemia rouleoux formation amyloidosis (AL) bence jones bone lesions anemia renal insufficiency ```
59
Ig a/w MM
IgG and IgA
60
Ig a/w waldenstrom
IgM
61
differentiate MM from waldenstrom
waldenstrom - IgM - hyperviscosity - no bone lesions
62
a/w painless lymph node involvement that fluctuates
follicular lymphoma
63
cells found in the follicular lymphoma
centrocytes -small cleaved cells
64
mutation in follicular lymphoma
bcl-2
65
what can cause adult t cell lymphoma
HTLV-1
66
mutation in burkits
c-myc
67
a/w with deactivation of cyclin D
mantle cell lymphoma

CK Heme Onc (13 decks)

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