Olanzepine Flashcards
1
Q
Presentations
A
5mg ODT
2
Q
Indications
A
- Mild agitation.
3
Q
Contraindications
A
- Hypersensitivity
4
Q
Precautions
A
- May be less effective if pt agitation is due to intoxication
- Elderly/frail and kids more susceptible to side effects
5
Q
Side effects
A
- Sedation
- Dizziness
- Extrapyramidal
- QT prolongation
6
Q
Pharmacology
A
Olanzepine is an atypical antipsychotic which works at multiple receptor sites especially 5-HT, dopamine and histamine. Olanzepine binds to dopamine receptors in the mesolimbic pathway blocking dopamine from having potential actions at the post synaptic receptor.
7
Q
Metabolism
A
Metabolised by the liver