Ceftriaxone

Question 1

Presentation

Answer 1

1g sterile powder

Question 2

Indications

Answer 2

1. Suspected meningococcal septicaemia

2. Severe sepsis

Question 3

Contraindications

Answer 3

Allergy to cephalosporin antibiotics

Question 4

Precautions

Answer 4

Allergy to penicillin

Question 5

Side effects

Answer 5

1. Rash
2. Nausea
3. Vomiting

Question 6

Pharmacology

Answer 6

Ceftriaxone is a cephalosporin antibiotic which inhibits mucopeptide synthesis in the bacterial cell wall. Ceftriaxone binds to enzymes in the bacterial cytoplasmic membrane causing them to lose activity leading to cell death

Question 7

How do you prepare the drug

Answer 7

IV - Ceftriaxone must be made up to 10ml using 9.5ml of sterile water and administered over 2mins
IM - Ceftriaxone must be made up to 4ml using 3.5ml 1% Lidnocaine and administered in lateral upper thigh

Question 8

Excretion

Answer 8

Excreted by the kidneys and bile