Olanzapine

Question 1

What is Olanzapine?

Answer 1

Atypical Antypsychotic

Question 2

What does Olanzapine do?

Answer 2

• Anatagonist at multiple receptor sites, particularly serotonin (5-HT), Dopamine, and Histamine

Question 3

What are some precautions of Olanzapine?

Answer 3

1. May be less effective if patients agitation is due to drug intoxication (especially stimulants) or alcohol withdrawal
2. Elderly/Frail patients and children are more susceptible to adverse effects

Question 4

What are some adverse effects of Olanzapine?

Answer 4

CNS: Sedation, Dizziness
Other: Extrapyramidal symptoms and QT prolongation are unlikely when administered at hte approved doses

Question 5

What are some significant interactions of Olanzapine?

Answer 5

1. Sedative medications/Alcohol - Over sedation due to synergistic effects

Question 6

How does Olanzapine present?

Answer 6

5mg ODT