Morphine Flashcards
1
Q
How does Morphine present
A
10mg/1mL
2
Q
Pharmacodynamics of Morphine
A
- Bind to Kappa, Mu receptors
- Mimics action of opioid peptides and antagonises to stimulate pain centres in CNS and spinal cord
3
Q
Morphine Contraindications
A
- Hypersensitivity
- Renal Impairment/failure
- Late second stage labour
4
Q
Morphine Precautions (8 Things)
A
- Elderly/frail
- Hypotension
- Respiratory Depression
- Current Asthma
- Respiratory tract burns
- Known Addiction to opioids
- Acute alcholism
- Patients on MAOIs
5
Q
Morphine Adverse effects
A
CNS: Drowsiness, respiratory depression, Euphoria, N+V, Addiction, Pin-point pupiles
Cardiovascular: Hypotension, Bradycardia
6
Q
Why is Morphine contraindicated in renal Impairment?
A
- Accumulation of Metabolites M3G and M6G mediates CNS depression and wont be cleared quick enough in renally impaired patients
7
Q
Why is morphine contraindicated in late second stage labour?
A
- Can cross the placental barrier and cause a baby to be born apnoeic
8
Q
After Morphine injection is whealts at the IV site a sign of Anaphylaxis?
A
No (Histamine release)
