Droperidol

Question 1

What is Droperidol?

Answer 1

Dopamine Antagonist

Question 2

What does Droperidol do?

Answer 2

• Antipsychotic medication with sedative effects
• Also block Alpha Receptors

Question 3

What are the contraindications for Droperidol?

Answer 3

• Nil

Question 4

What are the 4 precautions for Droperidol

Answer 4

1. Elderly Frail
2. Parkinson’s disease: May worsen parkinson related symtpoms
3. Lewy Body dementia: May experience increased agitation
4. QT prolongation has been reported rarely: ECG monitoring post sedation

Question 5

What are some adverse effects of Droperidol

Answer 5

CNS: Oversedation, Dizziness
CVS: Hypotension, Tachycardia, QT prolongation
Extrapyramidal Symtpoms

Question 6

What are 2 significant interactions of Droperidol?

Answer 6

1. Sedative Medications/Alcohol
2. Co-administration with ondansetron or prochlorperazine increases risk of QT prolongation

Question 7

How does droperidol present?

Answer 7

10mg in 2mL vial

Question 8

Onset time of Droperidol?

Answer 8

3 - 10minutes, peak sedation achieved within 20 - 30minutes

Question 9

Duration of action of Droperidol?

Answer 9

2 - 4 hours

Question 10

Is Droperidol safe to administer during pregnancy?

Answer 10

• Only if benefits outweigh risk

Question 11

Is Droperidol safe to administer during breastfeeding?

Answer 11

• Only if benefits outweigh risk
• Droperidol is excreted in breast milk, monitoring of infant is required