Obstructive Airway Diseases

Question 1

3 common obstructive airway diseases

Answer 1

chronic bronchitis

emphysema

asthma

Question 2

Bronchitis

Answer 2

inflammation of bronchial tubes

Question 3

emphysema

Answer 3

over inflation of alveoli

```
causes SOB
reduced/impaired gas exchange
~~~

Question 4

COPD is what two diseases?

Answer 4

emphysema

chronic bronchitis

Question 5

FVC

Answer 5

final total amount of air expired

Question 6

Spirometry predicts the FVC on

Answer 6

age
sex
height

(similar to peak expiratory flow rate)

Question 7

Normal PEFR

Answer 7

400-600 litres per min

Question 8

Obstructive lung disease FEV1/FVC/Ratio

Answer 8

FEV1 = 1.8l

FVC = 3.4l

FEV1/FVC= 0.53

Question 9

Clinical definition of bronchitis

Answer 9

cough productive of sputum most days in at least 3 consecutive months for 2 or more consecutive years

Question 10

Morphological changes in chronic bronchitis

large airways

Answer 10

Mucous gland hyperplasia

goblet cell hyperplasia

inflammation and fibrosis (minor component)

Question 11

Morphological changes in chronic bronchitis

small airways

Answer 11

Goblet cells appear

inflammation and fibrosis (in long standing disease)

Question 12

hyperplasia

Answer 12

enlargement of tissue or organ

increase in reproduction of cells etc

Question 13

Clinical definition of emphysema

Answer 13

increase beyond the normal in the size of airspaces distal to the terminal bronchiole arising either from dilatation or from destruction of their wall and without obvious fibrosis

Question 14

Bulla

Answer 14

emphysematous space greater than 1cm

Question 15

Bleb

Answer 15

a bulla just under the pleura

Question 16

Pathogenesis of emphysema includes

Answer 16

ageing
alpha-1-antitrypsin deficiency
SMOKING

Question 17

COPD is usually said to be

Answer 17

IRREVERSIBLE