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Obstetrics > Obstetric Cholestasis > Flashcards

Obstetric Cholestasis Flashcards

1
Q

What is obstetric cholestasis?

A

Intrahepatic stasis of bile flow in pregnancy

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2
Q

When does obstetric cholestasis usually present?

A

After 28 weeks

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3
Q

What are features of obstetric cholestasis?

A 
Pruritus - worse on palms/soles
Fatigue
Dark urine
Pale stools
Jaundice
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4
Q

What are key differentials for obstetric cholestasis?

A

Gallstones
Acute fatty liver of pregnancy
Hepatitis

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5
Q

What is acute fatty liver of pregnancy?

A

Rapid accumulation of fat in hepatocytes in 3rd trimester

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6
Q

What are features of acute fatty liver of pregnancy?

A

Jaundice
Malaise
N+V
Ascites

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7
Q

How is acute fatty liver of pregnancy managed?

A

Requires delivery of baby

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8
Q

How is suspected obstetric cholestasis investigated?

A

Bile acids

LFTs

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9
Q

Which LFT can be deranged normally in pregnancy?

A

ALP

Produced by placenta

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10
Q

How is obstetric cholestasis managed?

A

Ursodeoxycholic acid

Symptomatic relief for itch

  • Emollients
  • Anti-histamines
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Obstetrics (40 decks)

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